Il4r interleukin 4 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il4rprovided by RGD
Official Full Name: interleukin 4 receptorprovided by RGD
Primary source: RGD:2899
See related: Ensembl:ENSRNOG00000015441 AllianceGenome:RGD:2899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il4ra
Summary: Predicted to enable cytokine receptor activity. Involved in several processes, including ovulation; response to estrogen; and response to odorant. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 136.5), Adrenal (RPKM 114.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (189545739..189570639)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (180115061..180139981)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (196942343..196967221)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results suggest that oxidative stress may up-regulate IL-4 gene expression in mast cells via a decrease in HDAC activity.
Title: Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase.
In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only.
Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
Data show that IL-4 receptors are functionally competent in pancreatic beta-cells and that they signal via PI3K and JAK/STAT pathways.
Title: Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.
Increased of IL4Ra in glomeruli in induced Minimal change-like nephropathy.
Title: Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC18827P1 (e-PCR)
- UniSTS:271740

D1Smu6 (e-PCR)
- UniSTS:517783

D1S3691 (e-PCR)
- UniSTS:474269

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-4 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-4 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-4-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in production of molecular mediator involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-4 receptor subunit alpha

Names: IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133380.2 → NP_596871.2 interleukin-4 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_596871.2

Status: VALIDATED

Source sequence(s)

AB015747, AW527353, BQ204155

UniProtKB/Swiss-Prot

Q63257, Q9R1W8, Q9WTM8

UniProtKB/TrEMBL

A0A8L2R7Z3, A6I914

Related

ENSRNOP00000020994.2, ENSRNOT00000020994.6

Conserved Domains (2) summary

cd00063
Location:123 → 220

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09238
Location:32 → 121

IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

189545739..189570639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230215.5 → XP_006230277.1 interleukin-4 receptor subunit alpha isoform X1

See identical proteins and their annotated locations for XP_006230277.1

UniProtKB/Swiss-Prot

Q63257, Q9R1W8, Q9WTM8

UniProtKB/TrEMBL

A0A8L2R7Z3, A6I914

Conserved Domains (2) summary

cd00063
Location:123 → 220

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09238
Location:32 → 121

IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
XM_006230216.4 → XP_006230278.1 interleukin-4 receptor subunit alpha isoform X1

See identical proteins and their annotated locations for XP_006230278.1

UniProtKB/Swiss-Prot

Q63257, Q9R1W8, Q9WTM8

UniProtKB/TrEMBL

A0A8L2R7Z3, A6I914

Related

ENSRNOP00000073767.2

Conserved Domains (2) summary

cd00063
Location:123 → 220

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09238
Location:32 → 121

IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
XM_017588804.3 → XP_017444293.1 interleukin-4 receptor subunit alpha isoform X1

UniProtKB/Swiss-Prot

Q63257, Q9R1W8, Q9WTM8

UniProtKB/TrEMBL

A0A8L2R7Z3, A6I914

Conserved Domains (2) summary

cd00063
Location:123 → 220

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09238
Location:32 → 121

IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal