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    Gtf2i general transcription factor II I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353256, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Gtf2iprovided by RGD
    Official Full Name
    general transcription factor II Iprovided by RGD
    Primary source
    RGD:727961
    See related
    Ensembl:ENSRNOG00000001479 AllianceGenome:RGD:727961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtf2ird1
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and mitogen-activated protein kinase binding activity. Involved in negative regulation of cytosolic calcium ion concentration. Predicted to be located in cell projection; neuronal cell body; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GTF2I (general transcription factor IIi). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 287.1), Adrenal (RPKM 284.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2i in Genome Data Viewer
    Location:
    12q12
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (28037344..28112677)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22400933..22476243)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25410804..25487970)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 2 Neighboring gene GTF2I repeat domain containing 1 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene neutrophil cytosolic factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel splice variants in the 5'UTR of Gtf2i expressed in the rat brain: alternative 5'UTRs and differential expression in the neuronal dendrites. Shirai Y, et al. J Neurochem, 2015 Aug. PMID 25913238
    2. Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Hakre S, et al. Mol Cell, 2006 Oct 20. PMID 17052463
    3. TFII-I, a candidate gene for Williams syndrome cognitive profile: parallels between regional expression in mouse brain and human phenotype. Danoff SK, et al. Neuroscience, 2004. PMID 14751286
    4. Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development. Enkhmandakh B, et al. Proc Natl Acad Sci U S A, 2009 Jan 6. PMID 19109438, Free PMC Article
    5. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Olofsson P, et al. Nat Genet, 2003 Jan. PMID 12461526

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We identified seven novel Gtf2i transcripts with alternatively spliced 5'UTRs in the rat brain. In situ hybridization demonstrated a differential
      Title: Novel splice variants in the 5'UTR of Gtf2i expressed in the rat brain: alternative 5'UTRs and differential expression in the neuronal dendrites.
    2. observations suggest a model in which TFII-I suppresses agonist-induced calcium entry by competing with TRPC3 for binding to phospholipase C-gamma
      Title: Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94055

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor II-I
    Names
    GTFII-I
    TFII-I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001512.3 → NP_001001512.2  general transcription factor II-I isoform 1

      See identical proteins and their annotated locations for NP_001001512.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A1B0GWN0
      Related
      ENSRNOP00000040835.2, ENSRNOT00000040356.6
      Conserved Domains (1) summary
      pfam02946
      Location:112 → 184
      GTF2I; GTF2I-like repeat

    2. NM_001401209.1 → NP_001388138.1  general transcription factor II-I isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5U2Y1, Q80SX4
      UniProtKB/TrEMBL
      A6J0K2
      Related
      ENSRNOP00000002020.3, ENSRNOT00000002020.7

    3. NM_001401210.1 → NP_001388139.1  general transcription factor II-I isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6ALH4
      Related
      ENSRNOP00000095456.1, ENSRNOT00000109966.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      28037344..28112677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271417.1 → XP_063127487.1  general transcription factor II-I isoform X6

      UniProtKB/TrEMBL
      A0A8I6ALH4

    2. XM_063271421.1 → XP_063127491.1  general transcription factor II-I isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZRM5

    3. XM_008769141.3 → XP_008767363.1  general transcription factor II-I isoform X1

      See identical proteins and their annotated locations for XP_008767363.1

      UniProtKB/TrEMBL
      A0A0G2K4T7, A0A1B0GWN0
      Conserved Domains (1) summary
      pfam02946
      Location:112 → 184
      GTF2I; GTF2I-like repeat

    4. XM_006249170.5 → XP_006249232.1  general transcription factor II-I isoform X1

      See identical proteins and their annotated locations for XP_006249232.1

      UniProtKB/TrEMBL
      A0A0G2K4T7, A0A1B0GWN0
      Related
      ENSRNOP00000073166.1
      Conserved Domains (1) summary
      pfam02946
      Location:112 → 184
      GTF2I; GTF2I-like repeat

    5. XM_063271418.1 → XP_063127488.1  general transcription factor II-I isoform X7

      UniProtKB/TrEMBL
      A6J0K4

    6. XM_063271419.1 → XP_063127489.1  general transcription factor II-I isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZRM5

    7. XM_063271420.1 → XP_063127490.1  general transcription factor II-I isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZRM5

    8. XM_063271416.1 → XP_063127486.1  general transcription factor II-I isoform X6

      UniProtKB/TrEMBL
      A0A8I6ALH4

    9. XM_063271413.1 → XP_063127483.1  general transcription factor II-I isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4T7

    10. XM_063271415.1 → XP_063127485.1  general transcription factor II-I isoform X3

      UniProtKB/Swiss-Prot
      Q5U2Y1, Q80SX4
      UniProtKB/TrEMBL
      A6J0K2

    11. XM_063271410.1 → XP_063127480.1  general transcription factor II-I isoform X6

      UniProtKB/TrEMBL
      A0A8I6ALH4

    12. XM_063271408.1 → XP_063127478.1  general transcription factor II-I isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4T7

    13. XM_017598362.3 → XP_017453851.1  general transcription factor II-I isoform X4

      UniProtKB/TrEMBL
      A0A1B0GWN0, A0A8I6AST1
      Related
      ENSRNOP00000096595.1

    14. XM_017598360.3 → XP_017453849.1  general transcription factor II-I isoform X2

      UniProtKB/TrEMBL
      A0A1B0GWN0, A6J0J9
      Conserved Domains (1) summary
      pfam02946
      Location:112 → 184
      GTF2I; GTF2I-like repeat

    15. XM_017598363.3 → XP_017453852.1  general transcription factor II-I isoform X5

      UniProtKB/TrEMBL
      A0A1B0GWN0, A6J0K0
      Conserved Domains (1) summary
      pfam02946
      Location:112 → 184
      GTF2I; GTF2I-like repeat

    16. XM_063271409.1 → XP_063127479.1  general transcription factor II-I isoform X3

      UniProtKB/Swiss-Prot
      Q5U2Y1, Q80SX4
      UniProtKB/TrEMBL
      A6J0K2

    17. XM_063271411.1 → XP_063127481.1  general transcription factor II-I isoform X7

      UniProtKB/TrEMBL
      A6J0K4

    18. XM_063271414.1 → XP_063127484.1  general transcription factor II-I isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZRM5

    19. XM_017598366.3 → XP_017453855.1  general transcription factor II-I isoform X8

      UniProtKB/TrEMBL
      A0A1B0GWN0, A0A8I5ZK83
      Related
      ENSRNOP00000077117.1

    20. XM_017598370.3 → XP_017453859.1  general transcription factor II-I isoform X11

      UniProtKB/TrEMBL
      A0A1B0GWN0

    21. XM_017598369.3 → XP_017453858.1  general transcription factor II-I isoform X10

      UniProtKB/TrEMBL
      A0A1B0GWN0

    22. XM_039089536.2 → XP_038945464.1  general transcription factor II-I isoform X12

      Conserved Domains (1) summary
      pfam02946
      Location:200 → 274
      GTF2I; GTF2I-like repeat

    23. XM_039089537.2 → XP_038945465.1  general transcription factor II-I isoform X13

      Conserved Domains (1) summary
      pfam02946
      Location:179 → 253
      GTF2I; GTF2I-like repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2Y1.2 GenPept UniProtKB/Swiss-Prot:Q5U2Y1

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