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    Dusp26 dual specificity phosphatase 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306527, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dusp26provided by RGD
    Official Full Name
    dual specificity phosphatase 26provided by RGD
    Primary source
    RGD:1310090
    See related
    Ensembl:ENSRNOG00000011518 AllianceGenome:RGD:1310090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310090
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; p53 binding activity; and phosphatase activity. Predicted to be involved in several processes, including negative regulation of ERK1 and ERK2 cascade; protein dephosphorylation; and regulation of protein modification process. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human DUSP26 (dual specificity phosphatase 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 275.6), Brain (RPKM 135.5) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp26 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (67744830..67752673, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (61041784..61049319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (64798782..64806459, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene TELO2 interacting protein 2 Neighboring gene ring finger protein 122 Neighboring gene uncharacterized LOC134482403 Neighboring gene uncharacterized LOC120097498 Neighboring gene uncharacterized LOC134482554

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Vasudevan SA, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796912
    2. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Shang X, et al. Oncogene, 2010 Sep 2. PMID 20562916, Free PMC Article
    3. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Tanuma N, et al. Oncogene, 2009 Feb 5. PMID 19043453
    4. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Hu Y, et al. Mol Cell Biol, 2006 Apr. PMID 16581800, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109288

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 26
    Names
    dual specificity phosphatase 26 (putative)
    NP_001012352.1
    XP_006253294.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012352.1 → NP_001012352.1  dual specificity protein phosphatase 26

      See identical proteins and their annotated locations for NP_001012352.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089954
      UniProtKB/Swiss-Prot
      Q5FVI9
      UniProtKB/TrEMBL
      A6IVW2
      Related
      ENSRNOP00000015725.4, ENSRNOT00000015725.8
      Conserved Domains (1) summary
      cd00127
      Location:61 → 202
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      67744830..67752673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253232.5 → XP_006253294.1  dual specificity protein phosphatase 26 isoform X1

      See identical proteins and their annotated locations for XP_006253294.1

      UniProtKB/Swiss-Prot
      Q5FVI9
      UniProtKB/TrEMBL
      A6IVW2
      Conserved Domains (1) summary
      cd00127
      Location:61 → 202
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVI9.1 GenPept UniProtKB/Swiss-Prot:Q5FVI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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