Hacd3 3-hydroxyacyl-CoA dehydratase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hacd3provided by RGD
Official Full Name: 3-hydroxyacyl-CoA dehydratase 3provided by RGD
Primary source: RGD:1565496
See related: Ensembl:ENSRNOG00000030232 AllianceGenome:RGD:1565496
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptplad1; RGD1565496
Summary: Predicted to enable 3-hydroxyacyl-CoA dehydratase activity and enzyme binding activity. Predicted to be involved in several processes, including fatty acid biosynthetic process; positive regulation by virus of viral protein levels in host cell; and positive regulation of viral genome replication. Predicted to act upstream of or within I-kappaB kinase/NF-kappaB signaling; JNK cascade; and Rho protein signal transduction. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human HACD3 (3-hydroxyacyl-CoA dehydratase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 428.8), Brain (RPKM 218.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (74396441..74433700, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (65501240..65538507, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (70471572..70509874, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPLAD1 (HACD3)is in complex with insulin receptor in rat's liver plasma membrane and golgi-endosome(G/E). PTPLAD1 compartmentalization between PM and G/E is insulin-dependent. SiRNA-mediated knockdown of PTPLAD1 increased IR tyrosine phosphorylation and affect IR endocytosis in HEK293. PTPLAD1 depletion enhanced insulin effect on Glut2 translocation in HEK293 cells and it increased AKT-ser473 phosphorylation. [PTPLAD1]
Title: The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE119319 (e-PCR)
- UniSTS:249160

RH140787 (e-PCR)
- UniSTS:222853

RH141677 (e-PCR)
- UniSTS:223670

D8Got103 (e-PCR)
- UniSTS:111606

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by virus of viral protein levels in host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

Names: protein tyrosine phosphatase-like A domain containing 1

NP_001100301.1

EC 4.2.1.134

XP_063121228.1

EC 4.2.1.134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106831.1 → NP_001100301.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

See identical proteins and their annotated locations for NP_001100301.1

Status: PROVISIONAL

Source sequence(s)

CH473975

UniProtKB/TrEMBL

A6J5D7, D4ABI7

Related

ENSRNOP00000045049.4, ENSRNOT00000041915.5

Conserved Domains (2) summary

cd06465
Location:8 → 115

p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...

pfam04387
Location:195 → 355

PTPLA; Protein tyrosine phosphatase-like protein, PTPLA