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    Mphosph6 M phase phosphoprotein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686999, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mphosph6provided by RGD
    Official Full Name
    M phase phosphoprotein 6provided by RGD
    Primary source
    RGD:1591222
    See related
    Ensembl:ENSRNOG00000050087 AllianceGenome:RGD:1591222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in maturation of 5.8S rRNA. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of exosome (RNase complex). Orthologous to human MPHOSPH6 (M-phase phosphoprotein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 245.3), Brain (RPKM 117.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mphosph6 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (62768909..62778874, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (45860152..45870117, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (50357314..50367137, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098492 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 2 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene cadherin 13 Neighboring gene uncharacterized LOC120098661

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing. Yoshikatsu Y, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26166824
    2. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. Schilders G, et al. Nucleic Acids Res, 2007. PMID 17412707, Free PMC Article
    3. Identification of novel M phase phosphoproteins by expression cloning. Matsumoto-Taniura N, et al. Mol Biol Cell, 1996 Sep. PMID 8885239, Free PMC Article
    4. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Chen CY, et al. Cell, 2001 Nov 16. PMID 11719186
    5. Dis3-like 1: a novel exoribonuclease associated with the human exosome. Staals RH, et al. EMBO J, 2010 Jul 21. PMID 20531389, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    M-phase phosphoprotein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129881.3 → NP_001123353.1  M-phase phosphoprotein 6

      See identical proteins and their annotated locations for NP_001123353.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      B2RYS3
      Conserved Domains (1) summary
      pfam10175
      Location:8 → 136
      MPP6; M-phase phosphoprotein 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      62768909..62778874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278277.1 → XP_063134347.1  M-phase phosphoprotein 6 isoform X1

      UniProtKB/TrEMBL
      M0RDX0

    2. XM_063278278.1 → XP_063134348.1  M-phase phosphoprotein 6 isoform X2

    3. XM_039097984.2 → XP_038953912.1  M-phase phosphoprotein 6 isoform X3

      Related
      ENSRNOP00000067833.2
      Conserved Domains (1) summary
      pfam10175
      Location:1 → 118
      MPP6; M-phase phosphoprotein 6
    Nucleotide Protein Strain
    Heading Accession and Version

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