Pdcl phosducin like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdclprovided by RGD
Official Full Name: phosducin likeprovided by RGD
Primary source: RGD:621135
See related: Ensembl:ENSRNOG00000008484 AllianceGenome:RGD:621135
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Phlp; Pdcl1
Summary: Involved in negative regulation of protein refolding and protein folding. Predicted to be located in cytoplasm. Orthologous to human PDCL (phosducin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 207.2), Lung (RPKM 180.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (41519953..41529545, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (21110165..21119763, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (21602349..21609821, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that the interaction between PhLP and complex polypeptide 1 (CCT) may be a means to regulate CCT-dependent protein folding or alternatively, to control the availability of PhLP to modulate G protein signaling
Title: Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in heterotrimeric G-protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heterotrimeric G-protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein refolding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosducin-like protein

Names: phosducin-like 1

NP_071583.1

EC 1.14.99.1

XP_038961705.1

EC 1.14.99.1

XP_063140566.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022247.2 → NP_071583.1 phosducin-like protein

See identical proteins and their annotated locations for NP_071583.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4V8L9, Q63737, Q63738

UniProtKB/TrEMBL

A0A8I6A6H0, A6JES8

Related

ENSRNOP00000012160.2, ENSRNOT00000012160.6

Conserved Domains (2) summary

cd02987
Location:51 → 272

Phd_like_Phd; Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes ...

pfam02114
Location:35 → 299

Phosducin; Phosducin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

41519953..41529545 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105777.2 → XP_038961705.1 phosducin-like protein isoform X2

UniProtKB/TrEMBL

A6JES9

Conserved Domains (1) summary

pfam02114
Location:1 → 216

Phosducin
XM_063284496.1 → XP_063140566.1 phosducin-like protein isoform X1

UniProtKB/Swiss-Prot

Q4V8L9, Q63737, Q63738

UniProtKB/TrEMBL

A6JES8