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    Mmd2 monocyte to macrophage differentiation-associated 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304301, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mmd2provided by RGD
    Official Full Name
    monocyte to macrophage differentiation-associated 2provided by RGD
    Primary source
    RGD:1306506
    See related
    Ensembl:ENSRNOG00000001113 AllianceGenome:RGD:1306506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in several processes, including positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; and positive regulation of protein kinase activity. Predicted to be located in perinuclear region of cytoplasm. Orthologous to human MMD2 (monocyte to macrophage differentiation associated 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 427.6), Brain (RPKM 279.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (17075870..17123255)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11962733..12009776)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (14021724..14078121)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 29 member 4 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene Rap associating with DIL domain Neighboring gene poly(A) polymerase beta Neighboring gene adaptor related protein complex 5 subunit zeta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Jin T, et al. Cell Res, 2012 Apr. PMID 21968647, Free PMC Article
    2. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Kang P, et al. Neuron, 2012 Apr 12. PMID 22500632, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pore-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    monocyte to macrophage differentiation factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037217.1 → NP_001032294.1  monocyte to macrophage differentiation factor 2

      See identical proteins and their annotated locations for NP_001032294.1

      Status: VALIDATED

      Source sequence(s)
      BE096281, CB579379, CB748602, CO400908, CO404759, CO405970
      UniProtKB/TrEMBL
      A0A8I6ABL5, B1WBN0, F7F9F5
      Related
      ENSRNOP00000057341.2, ENSRNOT00000060608.4
      Conserved Domains (1) summary
      cl03831
      Location:35 → 235
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      17075870..17123255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271263.1 → XP_063127333.1  monocyte to macrophage differentiation factor 2 isoform X1

    2. XM_063271264.1 → XP_063127334.1  monocyte to macrophage differentiation factor 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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