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    Mtres1 mitochondrial transcription rescue factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683897, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mtres1provided by RGD
    Official Full Name
    mitochondrial transcription rescue factor 1provided by RGD
    Primary source
    RGD:1597785
    See related
    Ensembl:ENSRNOG00000047118 AllianceGenome:RGD:1597785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribosomal large subunit binding activity and tRNA binding activity. Predicted to be involved in regulation of mitochondrial transcription and rescue of stalled ribosome. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human MTRES1 (mitochondrial transcription rescue factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 274.6), Heart (RPKM 186.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtres1 in Genome Data Viewer
    Location:
    20q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (48604479..48622364, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (47022343..47038888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48276101..48294975, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A, pseudogene 5 Neighboring gene BEN domain containing 3 Neighboring gene fractured callus expressed transcript 1, pseudogene 1 Neighboring gene CD24 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria. Kotrys AV, et al. Nucleic Acids Res, 2019 Aug 22. PMID 31226201, Free PMC Article
    2. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial transcription rescue factor 1
    Names
    uncharacterized protein C6orf203 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109448.1 → NP_001102918.1  mitochondrial transcription rescue factor 1

      See identical proteins and their annotated locations for NP_001102918.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474025
      UniProtKB/TrEMBL
      A0A8I6ARF0, A6K6W9, M0R7R2, Q3B8P7
      Related
      ENSRNOP00000089834.1, ENSRNOT00000104066.1
      Conserved Domains (1) summary
      cl09940
      Location:126 → 228
      S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      48604479..48622364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256581.5 → XP_006256643.1  mitochondrial transcription rescue factor 1 isoform X2

      See identical proteins and their annotated locations for XP_006256643.1

      UniProtKB/TrEMBL
      A0A8I6ARF0, A6K6W9, M0R7R2, Q3B8P7
      Related
      ENSRNOP00000097401.1
      Conserved Domains (1) summary
      cl09940
      Location:126 → 228
      S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...

    2. XM_063279504.1 → XP_063135574.1  mitochondrial transcription rescue factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8Y4, M0R7R2

    3. XM_039099059.2 → XP_038954987.1  mitochondrial transcription rescue factor 1 isoform X3

      Conserved Domains (1) summary
      cl40612
      Location:131 → 179
      YlmH_RBD; Putative RNA-binding domain in YlmH
    Nucleotide Protein Strain
    Heading Accession and Version

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