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    Fcgbp Fc gamma binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100303643, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Fcgbpprovided by RGD
    Official Full Name
    Fc gamma binding proteinprovided by RGD
    Primary source
    RGD:2313189
    See related
    Ensembl:ENSRNOG00000019129 AllianceGenome:RGD:2313189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be active in extracellular matrix and extracellular space. Orthologous to human FCGBP (Fc fragment of IgG binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 33.3), Uterus (RPKM 31.1) and 7 other tissues See more
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    Genomic context

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    See Fcgbp in Genome Data Viewer
    Location:
    1q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92502461..92540658)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83374979..83413082)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85003280..85046840)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 4 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 105 Neighboring gene Fc fragment of IgG binding protein-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The rat IgGFcγBP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction. Yu H, et al. PLoS One, 2011. PMID 21629776, Free PMC Article
    2. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. Johansson ME, et al. J Proteome Res, 2009 Jul. PMID 19432394
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc fragment of IgG binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164657.3 → NP_001158129.3  Fc fragment of IgG binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZQD3, D3ZJF8
      Related
      ENSRNOP00000053950.5, ENSRNOT00000057122.5
      Conserved Domains (7) summary
      smart00216
      Location:2024 → 2180
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:2222 → 2296
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:775 → 829
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:56 → 210
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1917 → 1970
      TIL; Trypsin Inhibitor like cysteine rich domain
      cd19941
      Location:1530 → 1584
      TIL; trypsin inhibitor-like cysteine rich domain
      cl02516
      Location:2406 → 2560
      VWD; von Willebrand factor type D domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      92502461..92540658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108772.2 → XP_038964700.1  Fc fragment of IgG binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQD3, D3ZJF8
      Conserved Domains (7) summary
      smart00216
      Location:2024 → 2180
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:2222 → 2296
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:775 → 829
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:56 → 210
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1917 → 1970
      TIL; Trypsin Inhibitor like cysteine rich domain
      cd19941
      Location:1530 → 1584
      TIL; trypsin inhibitor-like cysteine rich domain
      cl02516
      Location:2406 → 2560
      VWD; von Willebrand factor type D domain
    Nucleotide Protein Strain
    Heading Accession and Version

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