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    Rwdd3 RWD domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65026, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rwdd3provided by RGD
    Official Full Name
    RWD domain containing 3provided by RGD
    Primary source
    RGD:620472
    See related
    Ensembl:ENSRNOG00000029893 AllianceGenome:RGD:620472
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rsume; X2cr1
    Summary
    Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of hypoxia-inducible factor-1alpha signaling pathway; and positive regulation of protein sumoylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human RWDD3 (RWD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 38.0), Lung (RPKM 36.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rwdd3 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (211918361..211933644, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209233622..209254842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (224710351..224723136, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553943 Neighboring gene U6 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene TLC domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In silico structural and functional characterization of the RSUME splice variants. Gerez J, et al. PLoS One, 2013. PMID 23469069, Free PMC Article
    2. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Carbia-Nagashima A, et al. Cell, 2007 Oct 19. PMID 17956732
    3. RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Shan B, et al. Endocr Relat Cancer, 2012 Feb. PMID 22009797
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of hypoxia-inducible factor-1alpha signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RWD domain-containing protein 3
    Names
    RWD domain-containing sumoylation enhancer
    RWD-containing sumoylation enhancer
    pituitary tumor X2CR1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128152.1 → NP_001121624.1  RWD domain-containing protein 3

      See identical proteins and their annotated locations for NP_001121624.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P0C7N0
      UniProtKB/TrEMBL
      A0A8L2QK58, A6HVD1
      Related
      ENSRNOP00000039966.4, ENSRNOT00000040080.5
      Conserved Domains (2) summary
      pfam05773
      Location:3 → 111
      RWD; RWD domain
      pfam06544
      Location:146 → 258
      DUF1115; Protein of unknown function (DUF1115)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      211918361..211933644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103082.2 → XP_038959010.1  RWD domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      pfam05773
      Location:3 → 111
      RWD; RWD domain

    2. XM_039103084.2 → XP_038959012.1  RWD domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam06544
      Location:48 → 160
      DUF1115; Protein of unknown function (DUF1115)

    3. XM_063282502.1 → XP_063138572.1  RWD domain-containing protein 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7N0.1 GenPept UniProtKB/Swiss-Prot:P0C7N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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