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    Dyrk4 dual-specificity tyrosine phosphorylation regulated kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 101320, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dyrk4provided by MGI
    Official Full Name
    dual-specificity tyrosine phosphorylation regulated kinase 4provided by MGI
    Primary source
    MGI:MGI:1330292
    See related
    Ensembl:ENSMUSG00000030345 AllianceGenome:MGI:1330292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dyrk4a; Dyrk4b
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 6.9) See more
    Orthologs
    human all
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    Genomic context

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    See Dyrk4 in Genome Data Viewer
    Location:
    6 F3; 6 61.92 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126852983..126899039, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126876020..126922083, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700018A23 gene Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:126799059-126799305 Neighboring gene A kinase anchor protein 3 Neighboring gene RAD51 associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E688 Neighboring gene STARR-positive B cell enhancer ABC_E6491 Neighboring gene metaxin 1 pseudogene Neighboring gene DNA segment, Chr 6, Wayne State University 163, expressed Neighboring gene STARR-positive B cell enhancer ABC_E8131

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. Papadopoulos C, et al. J Biol Chem, 2011 Feb 18. PMID 21127067, Free PMC Article
    2. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. Sacher F, et al. Mol Cell Endocrinol, 2007 Mar 15. PMID 17292540
    3. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. Becker W, et al. J Biol Chem, 1998 Oct 2. PMID 9748265
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.
      Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
    2. Dyrk4 is a testis-specific kinase with a very restricted expression to stage VIII postmeiotic spermatids.
      Title: The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 4
    Names
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
    NP_997093.2
    XP_006505316.1
    XP_006505318.1
    XP_006505319.1
    XP_011239406.1
    XP_011239407.1
    XP_011239409.1
    XP_036021600.1
    XP_036021601.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207210.3 → NP_997093.2  dual specificity tyrosine-phosphorylation-regulated kinase 4

      See identical proteins and their annotated locations for NP_997093.2

      Status: VALIDATED

      Source sequence(s)
      AC165085
      Consensus CDS
      CCDS20559.2
      UniProtKB/Swiss-Prot
      Q80WP9, Q8BI55
      Related
      ENSMUSP00000077606.6, ENSMUST00000078521.7
      Conserved Domains (2) summary
      smart00220
      Location:219 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:175 → 515
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126852983..126899039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241105.3 → XP_011239407.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X2

      Conserved Domains (1) summary
      cd14225
      Location:218 → 558
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    2. XM_011241104.3 → XP_011239406.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X1

      Conserved Domains (1) summary
      cd14225
      Location:228 → 568
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    3. XM_006505255.3 → XP_006505318.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X4

      Conserved Domains (1) summary
      cd14225
      Location:185 → 525
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    4. XM_006505253.1 → XP_006505316.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X3

      See identical proteins and their annotated locations for XP_006505316.1

      Conserved Domains (1) summary
      cd14225
      Location:209 → 549
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    5. XM_006505256.5 → XP_006505319.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X5

      Related
      ENSMUST00000032495.10
      Conserved Domains (1) summary
      cd14225
      Location:149 → 489
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    6. XM_036165708.1 → XP_036021601.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:1 → 232
      PKc_like; Protein Kinases, catalytic domain

    7. XM_011241107.3 → XP_011239409.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:228 → 486
      PKc_like; Protein Kinases, catalytic domain

    8. XM_036165707.1 → XP_036021600.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:228 → 488
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI55.1 GenPept UniProtKB/Swiss-Prot:Q8BI55

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