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    Ppp1r1c protein phosphatase 1, regulatory inhibitor subunit 1C [ Mus musculus (house mouse) ]

    Gene ID: 75276, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ppp1r1cprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory inhibitor subunit 1Cprovided by MGI
    Primary source
    MGI:MGI:1923185
    See related
    Ensembl:ENSMUSG00000034683 AllianceGenome:MGI:1923185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930565M23Rik; 4930579P15Rik
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within cell division. Predicted to be active in cytoplasm. Is expressed in nervous system. Orthologous to human PPP1R1C (protein phosphatase 1 regulatory inhibitor subunit 1C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C3; 2 47.58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79538124..79648890)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79707780..79818546)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39867 Neighboring gene ITPR interacting domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E2625 Neighboring gene STARR-seq mESC enhancer starr_04937 Neighboring gene STARR-seq mESC enhancer starr_04938 Neighboring gene STARR-seq mESC enhancer starr_04939 Neighboring gene phosphodiesterase 1A, calmodulin-dependent Neighboring gene predicted gene, 54166 Neighboring gene STARR-seq mESC enhancer starr_04941 Neighboring gene STARR-seq mESC enhancer starr_04942 Neighboring gene predicted gene 13674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Chen G, et al. Basic Res Cardiol, 2010 Sep. PMID 20512582, Free PMC Article
    2. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. Dykes IM, et al. J Neurosci, 2011 Jul 6. PMID 21734270, Free PMC Article
    3. Little skate genome provides insights into genetic programs essential for limb-based locomotion. Yoo D, et al. Elife, 2022 Oct 26. PMID 36288084, Free PMC Article
    4. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mitochondrial signaling and ERK activation may be involved in the I-1c cardioprotective effects against apoptosis induced by prolonged beta-adrenergic stimulation
      Title: Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 1C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290743.1 → NP_001277672.1  protein phosphatase 1 regulatory subunit 1C isoform b

      See identical proteins and their annotated locations for NP_001277672.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK051670, AK083940, AK157871
      Consensus CDS
      CCDS71081.1
      UniProtKB/Swiss-Prot
      Q8BKK4
      Related
      ENSMUSP00000107410.3, ENSMUST00000111780.3
      Conserved Domains (1) summary
      pfam05395
      Location:2 → 79
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

    2. NM_001290744.1 → NP_001277673.1  protein phosphatase 1 regulatory subunit 1C isoform c

      See identical proteins and their annotated locations for NP_001277673.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK051449, AK051670
      Consensus CDS
      CCDS79810.1
      UniProtKB/Swiss-Prot
      Q8BKK4
      Related
      ENSMUSP00000042784.5, ENSMUST00000040863.11
      Conserved Domains (1) summary
      pfam05395
      Location:2 → 48
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

    3. NM_172420.4 → NP_766008.2  protein phosphatase 1 regulatory subunit 1C isoform a

      See identical proteins and their annotated locations for NP_766008.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK051449, AK051670
      Consensus CDS
      CCDS16171.1
      UniProtKB/Swiss-Prot
      A2AQD1, Q3TZG5, Q8BKK4, Q8BKM4
      Related
      ENSMUSP00000088265.3, ENSMUST00000090760.9
      Conserved Domains (1) summary
      pfam05395
      Location:2 → 87
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

    RNA

    1. NR_110979.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK051670, AK083940, AK157871
      Related
      ENSMUST00000141978.2

    2. NR_110980.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks four 5' exons but contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK051449, AK051670

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      79538124..79648890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKK4.1 GenPept UniProtKB/Swiss-Prot:Q8BKK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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