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    Cpne3 copine III [ Mus musculus (house mouse) ]

    Gene ID: 70568, updated on 12-May-2024

    Summary

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    Official Symbol
    Cpne3provided by MGI
    Official Full Name
    copine IIIprovided by MGI
    Primary source
    MGI:MGI:1917818
    See related
    Ensembl:ENSMUSG00000028228 AllianceGenome:MGI:1917818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CPN3; 5430428M23Rik; 5730450C07Rik
    Summary
    Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.3), kidney adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A3; 4 7.53 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (19519252..19570108, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (19519252..19570108, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12393 Neighboring gene cyclic nucleotide gated channel beta 3 Neighboring gene SET pseudogene Neighboring gene STARR-seq mESC enhancer starr_09695 Neighboring gene STARR-seq mESC enhancer starr_09696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:19502117-19502304 Neighboring gene regulator of microtubule dynamics 1 Neighboring gene predicted gene, 52724 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene predicted gene 12353

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. Creutz CE, et al. J Biol Chem, 1998 Jan 16. PMID 9430674
    2. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Eom T, et al. Elife, 2013 Jan 22. PMID 23359859, Free PMC Article
    3. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
    4. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0636

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERBB2 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERBB2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    copine-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356481.1 → NP_001343410.1  copine-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK017651, AL683894, BC090632, BQ033175
      Conserved Domains (1) summary
      pfam07002
      Location:78 → 295
      Copine; Copine

    2. NM_027769.3 → NP_082045.1  copine-3 isoform 1

      See identical proteins and their annotated locations for NP_082045.1

      Status: VALIDATED

      Source sequence(s)
      AK017651, BC090632, BQ033175
      Consensus CDS
      CCDS17991.1
      UniProtKB/Swiss-Prot
      Q5CZX9, Q5DU22, Q8BT60
      UniProtKB/TrEMBL
      Q3UJS6
      Related
      ENSMUSP00000029885.5, ENSMUST00000029885.5
      Conserved Domains (3) summary
      cd04047
      Location:139 → 251
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      pfam07002
      Location:310 → 527
      Copine; Copine

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      19519252..19570108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BT60.2 GenPept UniProtKB/Swiss-Prot:Q8BT60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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