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    Atp5f1c ATP synthase F1 subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116550, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Atp5f1cprovided by RGD
    Official Full Name
    ATP synthase F1 subunit gammaprovided by RGD
    Primary source
    RGD:620011
    See related
    Ensembl:ENSRNOG00000019223 AllianceGenome:RGD:620011
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5c1
    Summary
    Contributes to ATP hydrolysis activity. Involved in ATP metabolic process and cellular response to nitric oxide. Located in mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1). Biomarker of schizophrenia. Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 5362.9), Muscle (RPKM 3755.3) and 8 other tissues See more
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    Genomic context

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    Location:
    17q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (73333584..73355872)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (68423927..68446169)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (72209321..72231562)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102546431 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene uncharacterized LOC120097843 Neighboring gene GATA binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. Sun L, et al. Brain Res Bull, 2018 Sep. PMID 30142370
    2. Thyroid hormone-related regulation of gene expression in human fatty liver. Pihlajamäki J, et al. J Clin Endocrinol Metab, 2009 Sep. PMID 19549744, Free PMC Article
    3. Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells. Tapia-Limonchi R, et al. Islets, 2014. PMID 25658244, Free PMC Article
    4. The 2.8-A structure of rat liver F1-ATPase: configuration of a critical intermediate in ATP synthesis/hydrolysis. Bianchet MA, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736690, Free PMC Article
    5. Mitochondrial ATP synthase: dramatic Mg2+-induced alterations in the structure and function of the F1-ATPase moiety. Pedersen PL, et al. Biochemistry, 1987 Dec 29. PMID 2894844

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nitric oxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit gamma, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
    F-ATPase gamma subunit
    NP_446277.1
    XP_006254291.1
    XP_006254292.1
    XP_006254293.1
    XP_063132091.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053825.2 → NP_446277.1  ATP synthase subunit gamma, mitochondrial

      See identical proteins and their annotated locations for NP_446277.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059158
      UniProtKB/TrEMBL
      A0A8I5YBP6, F7FFJ9, Q6PCU0
      Conserved Domains (1) summary
      TIGR01146
      Location:26 → 297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      73333584..73355872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276021.1 → XP_063132091.1  ATP synthase subunit gamma, mitochondrial isoform X1

      UniProtKB/TrEMBL
      F7FFJ9, Q6PCU0

    2. XM_006254230.5 → XP_006254292.1  ATP synthase subunit gamma, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_006254292.1

      UniProtKB/TrEMBL
      A0A8I5YBP6, A0A8J8YGG0
      Related
      ENSRNOP00000061946.4
      Conserved Domains (1) summary
      TIGR01146
      Location:26 → 297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    3. XM_006254229.3 → XP_006254291.1  ATP synthase subunit gamma, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006254291.1

      UniProtKB/TrEMBL
      A0A8I5YBP6, A0A8J8YGG0
      Conserved Domains (1) summary
      TIGR01146
      Location:26 → 297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    4. XM_006254231.5 → XP_006254293.1  ATP synthase subunit gamma, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      P35435
      Related
      ENSRNOP00000076528.1
      Conserved Domains (1) summary
      TIGR01146
      Location:2 → 273
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35435.2 GenPept UniProtKB/Swiss-Prot:P35435

    Gene LinkOut

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