Grsf1 G-rich RNA sequence binding factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grsf1provided by RGD
Official Full Name: G-rich RNA sequence binding factor 1provided by RGD
Primary source: RGD:1310858
See related: Ensembl:ENSRNOG00000003392 AllianceGenome:RGD:1310858
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of mitochondrial RNA catabolic process and regulation of RNA splicing. Predicted to act upstream of or within anterior/posterior pattern specification and morphogenesis of embryonic epithelium. Predicted to be located in mitochondrial nucleoid and ribonucleoprotein granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human GRSF1 (G-rich RNA sequence binding factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 529.3), Adrenal (RPKM 313.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (19696925..19713427)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (19412944..19429364)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (21039990..21056413)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guanine-rich RNA sequence binding factor 1 regulates neuronal ferroptosis after spinal cord injury in rats via the GPX4 signaling pathway.
Title: Guanine-rich RNA sequence binding factor 1 regulates neuronal ferroptosis after spinal cord injury in rats via the GPX4 signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140738 (e-PCR)
- UniSTS:222804

RH132147 (e-PCR)
- UniSTS:215430

BB232551 (e-PCR)
- UniSTS:207818

Grsf1 (e-PCR), detects polymorphism
- UniSTS:516560

C80280 (e-PCR)
- UniSTS:179189

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-rich sequence factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100890.1 → NP_001094360.1 G-rich sequence factor 1

Status: VALIDATED

Source sequence(s)

BC103654, CK474968, CK601425, FM050032

UniProtKB/TrEMBL

Q3SYP9

Conserved Domains (4) summary

COG0724
Location:328 → 458

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12505
Location:248 → 321

RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12730
Location:148 → 226

RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12733
Location:400 → 474

RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

19696925..19713427

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273070.1 → XP_063129140.1 G-rich sequence factor 1 isoform X1

UniProtKB/TrEMBL

A6KKI3
XM_006250775.5 → XP_006250837.1 G-rich sequence factor 1 isoform X3

UniProtKB/TrEMBL

F1LRK4

Related

ENSRNOP00000004551.7

Conserved Domains (3) summary

cd12505
Location:131 → 204

RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12730
Location:31 → 109

RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12733
Location:283 → 357

RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins
XM_063273071.1 → XP_063129141.1 G-rich sequence factor 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JTY6