Naga alpha-N-acetylgalactosaminidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nagaprovided by RGD
Official Full Name: alpha-N-acetylgalactosaminidaseprovided by RGD
Primary source: RGD:1306025
See related: Ensembl:ENSRNOG00000008064 AllianceGenome:RGD:1306025
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 157.7), Lung (RPKM 124.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (115726438..115735494, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (113846358..113855430, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (123563047..123572074, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-N-acetylgalactosaminidase activity	IEA Inferred from Electronic Annotation more info
enables alpha-N-acetylgalactosaminidase activity	ISO Inferred from Sequence Orthology more info
enables alpha-N-acetylgalactosaminidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-galactosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in carbohydrate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycolipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-N-acetylgalactosaminidase

Names: N-acetyl galactosaminidase, alpha; alpha-galactosidase B

NP_001012120.1

EC 3.2.1.49

XP_006242149.1

EC 3.2.1.49

XP_006242150.1

EC 3.2.1.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012120.1 → NP_001012120.1 alpha-N-acetylgalactosaminidase precursor

See identical proteins and their annotated locations for NP_001012120.1

Status: PROVISIONAL

Source sequence(s)

BC082084

UniProtKB/Swiss-Prot

Q66H12

UniProtKB/TrEMBL

A0A8I6B4W8, A6HT60

Conserved Domains (1) summary

cl07893
Location:25 → 394

AmyAc_family; Alpha amylase catalytic domain family