Cops6 COP9 signalosome subunit 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cops6provided by RGD
Official Full Name: COP9 signalosome subunit 6provided by RGD
Primary source: RGD:1309919
See related: Ensembl:ENSRNOG00000001346 AllianceGenome:RGD:1309919
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable isopeptidase activity and metallopeptidase activity. Predicted to be involved in protein deneddylation. Predicted to be located in nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS6 (COP9 signalosome subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 111.0), Brain (RPKM 103.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (22152688..22155527)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (17038979..17041818)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (19303387..19306226)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2.
Title: CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2.
CSN6 mediates PDGF-induced pulmonary arterial smooth muscle cells proliferation.
Title: COP9 signalosome subunit 6 mediates PDGF -induced pulmonary arterial smooth muscle cells proliferation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein deneddylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COP9 signalosome complex subunit 6

Names: COP9 (constitutive photomorphogenic) homolog, subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107129.1 → NP_001100599.1 COP9 signalosome complex subunit 6

See identical proteins and their annotated locations for NP_001100599.1

Status: PROVISIONAL

Source sequence(s)

CH474107

UniProtKB/TrEMBL

A6KSS5, D3ZI16

Related

ENSRNOP00000001820.4, ENSRNOT00000001820.5

Conserved Domains (1) summary

cd08063
Location:56 → 338

MPN_CSN6; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6