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    Klhl38 kelch-like 38 [ Mus musculus (house mouse) ]

    Gene ID: 268807, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klhl38provided by MGI
    Official Full Name
    kelch-like 38provided by MGI
    Primary source
    MGI:MGI:3045310
    See related
    Ensembl:ENSMUSG00000022357 AllianceGenome:MGI:3045310
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8230402K04Rik
    Summary
    Orthologous to human KLHL38 (kelch like family member 38). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 7.9), mammary gland adult (RPKM 1.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D1; 15 24.62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58176076..58187623, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58314573..58324169, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36112 Neighboring gene F-box protein 32 Neighboring gene predicted gene, 36193 Neighboring gene STARR-seq mESC enhancer starr_38751 Neighboring gene STARR-seq mESC enhancer starr_38752 Neighboring gene STARR-seq mESC enhancer starr_38753 Neighboring gene predicted gene, 53238 Neighboring gene annexin A13 Neighboring gene STARR-positive B cell enhancer ABC_E7369 Neighboring gene STARR-seq mESC enhancer starr_38755 Neighboring gene family with sequence similarity 91, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KLHL38 facilitates staurosporine-induced apoptosis in HL-1 cells via myocardin degradation. Luo Y, et al. IUBMB Life, 2022 May. PMID 35112472
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLHL38 facilitates staurosporine-induced apoptosis in HL-1 cells via myocardin degradation.
      Title: KLHL38 facilitates staurosporine-induced apoptosis in HL-1 cells via myocardin degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177755.3 → NP_808423.1  kelch-like protein 38

      Status: PROVISIONAL

      Source sequence(s)
      AK033353
      Consensus CDS
      CCDS27492.1
      UniProtKB/Swiss-Prot
      Q8BSF5
      Related
      ENSMUSP00000022985.2, ENSMUST00000022985.2
      Conserved Domains (7) summary
      smart00612
      Location:480 → 521
      Kelch; Kelch domain
      PHA03098
      Location:48 → 560
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:373 → 417
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:24 → 128
      BTB; BTB/POZ domain
      pfam01344
      Location:510 → 560
      Kelch_1; Kelch motif
      pfam07707
      Location:136 → 237
      BACK; BTB And C-terminal Kelch
      pfam13964
      Location:281 → 321
      Kelch_6; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58176076..58187623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159434.1 → XP_036015327.1  kelch-like protein 38 isoform X1

      Conserved Domains (4) summary
      PHA03098
      Location:48 → 438
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:322 → 370
      Kelch; KELCH repeat [structural motif]
      cd18476
      Location:131 → 229
      BACK_KLHL38; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38)
      cl38908
      Location:11 → 139
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSF5.1 GenPept UniProtKB/Swiss-Prot:Q8BSF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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