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    Ociad1 OCIA domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68095, updated on 12-May-2024

    Summary

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    Official Symbol
    Ociad1provided by MGI
    Official Full Name
    OCIA domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915345
    See related
    Ensembl:ENSMUSG00000029152 AllianceGenome:MGI:1915345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emi2; Imi2; OCIA; Asrij; TPA018; 6030432N09Rik; B230209J16Rik
    Summary
    Involved in regulation of stem cell differentiation. Located in endosome. Is expressed in several structures, including cardiovascular system; gonad; limb bud; neural ectoderm; and trunk mesenchyme. Orthologous to human OCIAD1 (OCIA domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 27.0), frontal lobe adult (RPKM 24.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ociad1 in Genome Data Viewer
    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73450093..73471420)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73292769..73314077)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700025M24 gene Neighboring gene STARR-seq mESC enhancer starr_13383 Neighboring gene predicted gene, 40316 Neighboring gene STARR-seq mESC enhancer starr_13384 Neighboring gene OCIA domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13385 Neighboring gene predicted gene, 34496

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages. Li X, et al. EBioMedicine, 2020 Jan. PMID 31931285, Free PMC Article
    2. Embryonic stem cell and tissue-specific expression of a novel conserved gene, asrij. Mukhopadhyay A, et al. Dev Dyn, 2003 Aug. PMID 12889067
    3. Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence. Sinha S, et al. Blood, 2019 May 30. PMID 30952670
    4. Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency. Sinha A, et al. Cell Rep, 2013 Aug 29. PMID 23972987, Free PMC Article
    5. Identification of novel genes expressed during metanephric induction through single-cell library screening. Abidari JM, et al. Kidney Int, 2000 Jun. PMID 10844592

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.
      Title: OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.
    2. Asrij sequesters CSN5 via its conserved OCIA domain, thereby preventing p53 degradation.
      Title: Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence.
    3. Asrij regulates mouse embryonic stem cell pluripotency via JAK/STAT signaling.
      Title: Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency.
    4. Asrij is expressed predominantly in mouse embryonic blood vessels; a splice variant is expressed in the brain, and can serve as an early stem cell marker.
      Title: Embryonic stem cell and tissue-specific expression of a novel conserved gene, asrij.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    OCIA domain-containing protein 1
    Names
    expressed during mesenchymal induction 2
    induced during mesenchymal induction 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159887.1 → NP_001153359.1  OCIA domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001153359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK077904, AK078102, CX238085
      Consensus CDS
      CCDS80300.1
      UniProtKB/Swiss-Prot
      Q9CRD0
      Related
      ENSMUSP00000144515.2, ENSMUST00000200935.4
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    2. NM_001159888.1 → NP_001153360.1  OCIA domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001153360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 3' coding region, compared to variant 1, which result in a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK077904, AK078102, CX238454
      Consensus CDS
      CCDS51518.1
      UniProtKB/Swiss-Prot
      Q9CRD0
      Related
      ENSMUSP00000069412.7, ENSMUST00000071081.13
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    3. NM_001159889.1 → NP_001153361.1  OCIA domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001153361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has a distinct 3' terminus, compared to variant 1, which results in a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AC108828, AK078102
      Consensus CDS
      CCDS51518.1
      UniProtKB/Swiss-Prot
      Q9CRD0
      Related
      ENSMUSP00000128805.2, ENSMUST00000166823.5
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    4. NM_023429.4 → NP_075918.1  OCIA domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_075918.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK077904, AK078102
      Consensus CDS
      CCDS19339.1
      UniProtKB/Swiss-Prot
      Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
      Related
      ENSMUSP00000031038.5, ENSMUST00000031038.11
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      73450093..73471420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165449.1 → XP_036021342.1  OCIA domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    2. XM_030254780.2 → XP_030110640.1  OCIA domain-containing protein 1 isoform X4

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    3. XM_017321083.3 → XP_017176572.1  OCIA domain-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q9CRD0
      Related
      ENSMUSP00000143799.2, ENSMUST00000202250.4
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    4. XM_017321082.2 → XP_017176571.1  OCIA domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9CRD0
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    5. XM_036165451.1 → XP_036021344.1  OCIA domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    6. XM_036165450.1 → XP_036021343.1  OCIA domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    7. XM_030254779.2 → XP_030110639.1  OCIA domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    8. XM_006504075.4 → XP_006504138.1  OCIA domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006504138.1

      UniProtKB/Swiss-Prot
      Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    9. XM_030254778.2 → XP_030110638.2  OCIA domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    10. XM_036165453.1 → XP_036021346.1  OCIA domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    11. XM_036165455.1 → XP_036021348.1  OCIA domain-containing protein 1 isoform X4

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    12. XM_036165454.1 → XP_036021347.1  OCIA domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    13. XM_036165452.1 → XP_036021345.1  OCIA domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    14. XM_006504076.5 → XP_006504139.1  OCIA domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006504139.1

      UniProtKB/Swiss-Prot
      Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
      Conserved Domains (1) summary
      pfam07051
      Location:24 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    RNA

    1. XR_376823.5 RNA Sequence

    2. XR_001784740.3 RNA Sequence

    3. XR_003955702.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRD0.1 GenPept UniProtKB/Swiss-Prot:Q9CRD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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