Atp5f1b ATP synthase F1 subunit beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5f1bprovided by MGI
Official Full Name: ATP synthase F1 subunit betaprovided by MGI
Primary source: MGI:MGI:107801
See related: Ensembl:ENSMUSG00000025393 AllianceGenome:MGI:107801
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atp5b
Summary: Predicted to enable several functions, including adenyl ribonucleotide binding activity; angiostatin binding activity; and proton-transporting ATPase activity, rotational mechanism. Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Acts upstream of or within cellular response to interleukin-7; lipid metabolic process; and negative regulation of cell adhesion involved in substrate-bound cell migration. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; eye; heart; and integumental system. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 1957.4), kidney adult (RPKM 1315.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.39 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127919176..127926257)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128083307..128090388)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted inhibition of ATP5B gene prevents bone erosion in collagen-induced arthritis by inhibiting osteoclastogenesis.
Title: Targeted inhibition of ATP5B gene prevents bone erosion in collagen-induced arthritis by inhibiting osteoclastogenesis.
The results of this study found that the expression levels of Cd68 and Atp5b were significantly correlated with the neurofibrillary tangle burden in the Alzheimer's Disease brain and with their cognition.
Title: Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model.
Results show that the relationship between ATPsyn-beta and insulin secretion deficiency suggests that ATPsyn-beta potentially could serve as a marker for type 2 diabetes mellitus disease risk in women with polycystic ovary syndrome.
Title: ATP synthase β-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Data show that overexpressed ATP synthase subunit-beta (ATP5b) was significantly located on renal proximal tubules in db/db mice.
Title: ATP synthase subunit-β down-regulation aggravates diabetic nephropathy.
Aging altered the expression of ATP synthase subunit beta.
Title: Proteomic profiling of aging in glomeruli of mice by using two-dimensional differential gel electrophoresis.
inhibition of calmodulin (CaM) completely abolished ATPSbeta-induced Akt activation in liver cells
Title: Hepatic overexpression of ATP synthase β subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice.
association of calcium channel alpha2/delta subunit 1 and ATP5b occurs in intracellular membranes and at the plasma membrane of developing muscle cells, where they form a signaling complex capable of accelerating the rate of decline of calcium transients
Title: The calcium channel α2/δ1 subunit interacts with ATP5b in the plasma membrane of developing muscle cells.
Adipocyte recycling of apoA-I is a selective process that involves the ectopically expressed beta-subunit of ATP synthase.
Title: The β-subunit of ATP synthase is involved in cellular uptake and resecretion of apoA-I but does not control apoA-I-induced lipid efflux in adipocytes.
Disturbed flow and hypercholesterolemia synergistically promote gamma/delta T-lymphocyte activation by the membrane translocation of ATPSbeta in endothelial cells.
Title: A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain.
CyPD association to the lateral stalk of ATP synthase modulates the activity of the complex
Title: Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Atp5b (e-PCR), detects polymorphism
- UniSTS:141131

D17Wsu164e (e-PCR), detects polymorphism
- UniSTS:142173

AW549786 (e-PCR)
- UniSTS:209334

ATP5B (e-PCR)
- UniSTS:262101

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
contributes_to ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables angiostatin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info
enables proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info
enables proton-transporting ATPase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-7	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell adhesion involved in substrate-bound cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven mitochondrial ATP synthesis	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP synthase subunit beta, mitochondrial

Names: ATP synthase, H+ transporting mitochondrial F1 complex, alpha subunit; ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit; mitochondrial ATP synthase, H+ transporting F1 complex beta subunit

NP_058054.2

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.