Myo1g myosin IG [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo1gprovided by MGI
Official Full Name: myosin IGprovided by MGI
Primary source: MGI:MGI:1927091
See related: Ensembl:ENSMUSG00000020437 AllianceGenome:MGI:1927091
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E430002D17Rik
Summary: Enables phosphatidylinositol-3,4,5-trisphosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in Fc-gamma receptor signaling pathway involved in phagocytosis and T cell mediated immunity. Acts upstream of or within several processes, including T cell meandering migration; cell gliding; and phagocytosis. Located in several cellular components, including lamellipodium; microvillus; and phagocytic cup. Orthologous to human MYO1G (myosin IG). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 76.0), thymus adult (RPKM 51.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 4.3 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (6456548..6470960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (6506548..6520960, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes.
Title: Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes.
The results described here reveal a novel molecular mechanism by which Myo1g mediates and regulates cell stiffness in B-lymphocytes.
Title: Myo1g is an active player in maintaining cell stiffness in B-lymphocytes.
Study found that the unconventional myosin 1g (Myo1g) motor generates membrane tension, enforces cell-intrinsic meandering search, and enhances T-DC interactions during lymph-node surveillance. Increased turning and meandering motility, as opposed to ballistic motility, is enhanced by Myo1g. Myo1g acts as a "turning motor" and generates a form of cellular "flanerie."
Title: Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.
Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes.
Title: Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes.
Data propose that Myo1G regulates cell elasticity by deformations of the actin network at the cell cortex.
Title: Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	TAS Traceable Author Statement more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell meandering migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell gliding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in leading edge membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-Ig

Names: myosin 1G; myosin-Ig

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178440.4 → NP_848534.2 unconventional myosin-Ig

See identical proteins and their annotated locations for NP_848534.2

Status: VALIDATED

Source sequence(s)

AK030825, AK152797, AK171505

Consensus CDS

CCDS24421.1

UniProtKB/Swiss-Prot

Q5SUA5, Q8BIT8, Q8BJ17, Q8BJ65, Q8R019, Q91ZI1

Related

ENSMUSP00000003459.4, ENSMUST00000003459.4

Conserved Domains (3) summary

smart00242
Location:10 → 712

MYSc; Myosin. Large ATPases

cd01378
Location:29 → 700

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:821 → 1015

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

6456548..6470960 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514702.1 → XP_006514765.1 unconventional myosin-Ig isoform X2

Conserved Domains (2) summary

cd01378
Location:1 → 606

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:727 → 898

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006514700.1 → XP_006514763.1 unconventional myosin-Ig isoform X1

Conserved Domains (2) summary

cd01378
Location:52 → 715

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:836 → 1007

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding