Lyzl1 lysozyme-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyzl1provided by MGI
Official Full Name: lysozyme-like 1provided by MGI
Primary source: MGI:MGI:1914578
See related: Ensembl:ENSMUSG00000024233 AllianceGenome:MGI:1914578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyc2; Lyzd1; 1700038F02Rik
Summary: Predicted to enable lysozyme activity. Predicted to be located in extracellular region. Orthologous to several human genes including LYZL2 (lysozyme like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 49.1) See more
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Genomic context

Location:: 18 A1; 18 2.57 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (4165862..4182232)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (4165832..4182236)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysozyme-like protein 1

Names: lysozyme d1; lysozyme-like protein 2

NP_001403180.1

EC 3.2.1.17

NP_080368.1

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416251.1 → NP_001403180.1 lysozyme-like protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC123048

UniProtKB/TrEMBL

D3Z796

Related

ENSMUSP00000113101.2, ENSMUST00000120837.2
NM_026092.4 → NP_080368.1 lysozyme-like protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_080368.1

Status: VALIDATED

Source sequence(s)

AC123048

Consensus CDS

CCDS29035.1

UniProtKB/Swiss-Prot

Q9CPX3

UniProtKB/TrEMBL

A0A077S9Z4

Related

ENSMUSP00000025076.4, ENSMUST00000025076.10

Conserved Domains (1) summary

cd00119
Location:20 → 143

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...