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    Tmem87b transmembrane protein 87B [ Mus musculus (house mouse) ]

    Gene ID: 72477, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tmem87bprovided by MGI
    Official Full Name
    transmembrane protein 87Bprovided by MGI
    Primary source
    MGI:MGI:1919727
    See related
    Ensembl:ENSMUSG00000014353 AllianceGenome:MGI:1919727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610301K12Rik; 2810431I02Rik
    Summary
    Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and membrane. Is expressed in medulla oblongata; medulla oblongata basal plate mantle layer; and spinal cord. Orthologous to human TMEM87B (transmembrane protein 87B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.7), placenta adult (RPKM 10.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 62.63 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128659991..128696181)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128818303..128854261)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E4498 Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_05650 Neighboring gene STARR-seq mESC enhancer starr_05651 Neighboring gene STARR-positive B cell enhancer ABC_E2046 Neighboring gene fibulin 7 Neighboring gene STARR-seq mESC enhancer starr_05654 Neighboring gene STARR-positive B cell enhancer ABC_E7861 Neighboring gene zinc finger CCCH type containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 87B
    Names
    novel lung seven transmembrane receptor domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355628.1 → NP_001342557.1  transmembrane protein 87B isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK011959, AL808104
      UniProtKB/TrEMBL
      Z4YML9
      Related
      ENSMUSP00000119093.2, ENSMUST00000152210.2
      Conserved Domains (1) summary
      pfam06814
      Location:175 → 467
      Lung_7-TM_R; Lung seven transmembrane receptor

    2. NM_001355629.1 → NP_001342558.1  transmembrane protein 87B isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL808104
      Consensus CDS
      CCDS89553.1
      UniProtKB/TrEMBL
      A0A5F8MPT2, Z4YML9
      Related
      ENSMUSP00000159105.2, ENSMUST00000143398.3
      Conserved Domains (1) summary
      pfam06814
      Location:175 → 459
      Lung_7-TM_R; Lung seven transmembrane receptor

    3. NM_028248.2 → NP_082524.2  transmembrane protein 87B isoform b precursor

      See identical proteins and their annotated locations for NP_082524.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AI449240, AK011959, AK050955, AL808104, BY482777, CA479832, CN458042
      Consensus CDS
      CCDS38234.1
      UniProtKB/Swiss-Prot
      A2AN76, Q3T9D2, Q8BKU8, Q8K0G0, Q9D001
      UniProtKB/TrEMBL
      Z4YML9
      Related
      ENSMUSP00000105954.2, ENSMUST00000110325.8
      Conserved Domains (1) summary
      pfam06814
      Location:175 → 459
      Lung_7-TM_R; Lung seven transmembrane receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      128659991..128696181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940742.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKU8.1 GenPept UniProtKB/Swiss-Prot:Q8BKU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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