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    Ints4 integrator complex subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 101861, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ints4provided by MGI
    Official Full Name
    integrator complex subunit 4provided by MGI
    Primary source
    MGI:MGI:1917164
    See related
    Ensembl:ENSMUSG00000025133 AllianceGenome:MGI:1917164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610034N24Rik
    Summary
    Predicted to be involved in snRNA processing. Predicted to be located in nucleolus. Predicted to be part of integrator complex. Is expressed in axial musculature; medulla oblongata basal plate; olfactory cortex marginal layer; submandibular gland primordium; and telencephalon ventricular layer. Orthologous to human INTS4 (integrator complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.6), ovary adult (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints4 in Genome Data Viewer
    Location:
    7 E1; 7 53.52 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97130158..97190605)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97480951..97541398)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19596 Neighboring gene predicted gene, 32945 Neighboring gene potassium channel tetramerisation domain containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E4950 Neighboring gene predicted gene, 24412 Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, pseudogene 1 Neighboring gene remodeling and spacing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. St-Denis N, et al. Cell Rep, 2016 Nov 22. PMID 27880917
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 4
    Names
    int4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358012.1 → NP_001344941.1  integrator complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149605
      Conserved Domains (2) summary
      sd00044
      Location:367 → 394
      HEAT; HEAT repeat [structural motif]
      cl26317
      Location:371 → 452
      Adaptin_N; Adaptin N terminal region

    2. NM_027256.2 → NP_081532.1  integrator complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_081532.1

      Status: VALIDATED

      Source sequence(s)
      AC149605, AK011676, AW493223, CA450656, CF724981, CX218921, CX565861
      Consensus CDS
      CCDS21460.1
      UniProtKB/Swiss-Prot
      Q3TQQ4, Q8C2H1, Q8CIM8, Q91YV5, Q9CSY4
      Related
      ENSMUSP00000026126.9, ENSMUST00000026126.10
      Conserved Domains (2) summary
      COG1413
      Location:52 → 257
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:200 → 222
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97130158..97190605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030241963.1 → XP_030097823.1  integrator complex subunit 4 isoform X2

      Conserved Domains (2) summary
      sd00044
      Location:366 → 393
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:370 → 451
      Adaptin_N; Adaptin N terminal region

    2. XM_006507179.4 → XP_006507242.1  integrator complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006507242.1

      Conserved Domains (3) summary
      COG1413
      Location:51 → 256
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:199 → 221
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:379 → 460
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIM8.1 GenPept UniProtKB/Swiss-Prot:Q8CIM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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