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    Virma vir like m6A methyltransferase associated [ Mus musculus (house mouse) ]

    Gene ID: 66185, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Virmaprovided by MGI
    Official Full Name
    vir like m6A methyltransferase associatedprovided by MGI
    Primary source
    MGI:MGI:1913435
    See related
    Ensembl:ENSMUSG00000040720 AllianceGenome:MGI:1913435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa1429; mKIAA1429; 1110037F02Rik; 4930422M05Rik
    Summary
    Predicted to be involved in mRNA alternative polyadenylation and mRNA methylation. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in cytoplasm and nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human VIRMA (vir like m6A methyltransferase associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.4), CNS E11.5 (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A1; 4 5.11 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11485958..11551143)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11485958..11551143)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09598 Neighboring gene predicted gene, 35631 Neighboring gene predicted gene 11821 Neighboring gene STARR-positive B cell enhancer ABC_E4613 Neighboring gene STARR-seq mESC enhancer starr_09599 Neighboring gene STARR-positive B cell enhancer ABC_E338 Neighboring gene STARR-seq mESC enhancer starr_09600 Neighboring gene STARR-positive B cell enhancer ABC_E4614 Neighboring gene predicted gene, 53245 Neighboring gene predicted gene, 35693 Neighboring gene RAD54 homolog B (S. cerevisiae) Neighboring gene fibrinogen silencer binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells. Wang L, et al. Cancer Sci, 2023 Apr. PMID 36572002, Free PMC Article
    2. Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m(6)A deposition to activate the PI3K/AKT signaling. Xu CL, et al. Reprod Biol, 2022 Dec. PMID 35987159
    3. Oocyte competence is maintained by m(6)A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development. Hu Y, et al. Cell Death Differ, 2020 Aug. PMID 32094512, Free PMC Article
    4. N(6)-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. Wu Y, et al. Nat Cell Biol, 2022 Jun. PMID 35606490
    5. The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Ito-Kureha T, et al. Nat Immunol, 2022 Aug. PMID 35879451

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells.
      Title: KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells.
    2. Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m[6]A deposition to activate the PI3K/AKT signaling.
      Title: Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m(6)A deposition to activate the PI3K/AKT signaling.
    3. Oocyte competence is maintained by m(6)A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development.
      Title: Oocyte competence is maintained by m(6)A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA alternative polyadenylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein virilizer homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081183.1 → NP_001074652.1  protein virilizer homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL732538, AL772170
      Consensus CDS
      CCDS38693.1
      UniProtKB/TrEMBL
      E9PZY8
      Related
      ENSMUSP00000103943.3, ENSMUST00000108307.3
      Conserved Domains (2) summary
      pfam15502
      Location:1752 → 1857
      MPLKIP; M-phase-specific PLK1-interacting protein
      pfam15912
      Location:5 → 236
      VIR_N; Virilizer, N-terminal

    2. NM_001347055.1 → NP_001333984.1  protein virilizer homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL732538, AL772170
      Consensus CDS
      CCDS84705.1
      UniProtKB/Swiss-Prot
      A2AIV1, A2AIV2, Q3TDQ3, Q3TRR9, Q3U1Z2, Q80TD6, Q8C758, Q8K151, Q9CSI3
      Related
      ENSMUSP00000058078.7, ENSMUST00000059914.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      11485958..11551143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AIV2.1 GenPept UniProtKB/Swiss-Prot:A2AIV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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