Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pafah1b3provided by RGD
Official Full Name: platelet-activating factor acetylhydrolase 1b, catalytic subunit 3provided by RGD
Primary source: RGD:620333
See related: Ensembl:ENSRNOG00000020481 AllianceGenome:RGD:620333
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity. Contributes to platelet-activating factor acetyltransferase activity. Involved in brain development. Located in cytosol. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Orthologous to human PAFAH1B3 (platelet activating factor acetylhydrolase 1b catalytic subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 53.4), Kidney (RPKM 46.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (90009085..90011611, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80881263..80883789, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (82163733..82166259, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that PAF induces synaptic facilitation through activation of CaMKII, PKC and ERK in the hippocampal CA1 region.
Title: Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Rat96 (e-PCR)
- UniSTS:118630

RH133477 (e-PCR)
- UniSTS:216760

Pafah1b3 (e-PCR), detects polymorphism
- UniSTS:144117

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to platelet-activating factor acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables platelet-activating factor acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex	IDA Inferred from Direct Assay more info	PubMed
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet-activating factor acetylhydrolase IB subunit alpha1

Names: PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH alpha 1; PAF-AH subunit gamma; PAFAH subunit gamma; platelet-activating factor acetylhydrolase IB subunit gamma; platelet-activating factor acetylhydrolase alpha 1 subunit

NP_446106.1

EC 3.1.1.47

XP_006228427.1

EC 3.1.1.47

XP_017444141.1

EC 3.1.1.47

XP_063118429.1

EC 3.1.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053654.3 → NP_446106.1 platelet-activating factor acetylhydrolase IB subunit alpha1

See identical proteins and their annotated locations for NP_446106.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O35263

UniProtKB/TrEMBL

A6J951

Related

ENSRNOP00000027774.2, ENSRNOT00000027774.5

Conserved Domains (1) summary

cd01820
Location:8 → 206

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

90009085..90011611 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228365.4 → XP_006228427.1 platelet-activating factor acetylhydrolase IB subunit alpha1 isoform X1

See identical proteins and their annotated locations for XP_006228427.1

UniProtKB/Swiss-Prot

O35263

UniProtKB/TrEMBL

A6J951

Conserved Domains (1) summary

cd01820
Location:8 → 206

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
XM_063262359.1 → XP_063118429.1 platelet-activating factor acetylhydrolase IB subunit alpha1 isoform X1

UniProtKB/Swiss-Prot

O35263

UniProtKB/TrEMBL

A6J951
XM_017588652.3 → XP_017444141.1 platelet-activating factor acetylhydrolase IB subunit alpha1 isoform X1

UniProtKB/Swiss-Prot

O35263

UniProtKB/TrEMBL

A6J951

Conserved Domains (1) summary

cd01820
Location:8 → 206

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...