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    Utp25 UTP25 small subunit processome component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305076, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Utp25provided by RGD
    Official Full Name
    UTP25 small subunit processome componentprovided by RGD
    Primary source
    RGD:1359148
    See related
    Ensembl:ENSRNOG00000004789 AllianceGenome:RGD:1359148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Def; Diexf
    Summary
    Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein destabilization; and protein localization to nucleolus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human UTP25 (UTP25 small subunit processor component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 68.6), Spleen (RPKM 64.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Utp25 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107159092..107180361, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104630390..104651681, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (111828052..111849654, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481546 Neighboring gene uncharacterized LOC120096359 Neighboring gene uncharacterized LOC120096360 Neighboring gene interferon regulatory factor 6 Neighboring gene similar to human chromosome 1 open reading frame 74 Neighboring gene TRAF3 interacting protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. Aryal NK, et al. Oncotarget, 2017 Nov 28. PMID 29262616, Free PMC Article
    2. Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Tao T, et al. Cell Res, 2013 May. PMID 23357851, Free PMC Article
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables U3 snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic organ development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar RNA-associated protein 25 homolog
    Names
    UTP25, small subunit processor component
    novel putative protein similar to YIL091C yeast hypothetical 84 kD protein from SGA1-KTR7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013986.2 → NP_001014008.1  U3 small nucleolar RNA-associated protein 25 homolog

      See identical proteins and their annotated locations for NP_001014008.1

      Status: VALIDATED

      Source sequence(s)
      BC087114, CB569988
      UniProtKB/Swiss-Prot
      Q5M9G7
      UniProtKB/TrEMBL
      A6JH19
      Related
      ENSRNOP00000006395.4, ENSRNOT00000006395.7
      Conserved Domains (1) summary
      pfam06862
      Location:283 → 758
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      107159092..107180361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272402.1 → XP_063128472.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M9G7.1 GenPept UniProtKB/Swiss-Prot:Q5M9G7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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