Aldh8a1 aldehyde dehydrogenase 8 family, member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh8a1provided by RGD
Official Full Name: aldehyde dehydrogenase 8 family, member A1provided by RGD
Primary source: RGD:1590218
See related: Ensembl:ENSRNOG00000014907 AllianceGenome:RGD:1590218
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable retinal dehydrogenase activity. Predicted to be involved in retinal metabolic process and retinoic acid metabolic process. Predicted to act upstream of or within 9-cis-retinoic acid biosynthetic process. Orthologous to human ALDH8A1 (aldehyde dehydrogenase 8 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1293.6) and Liver (RPKM 1122.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (18003507..18022952)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (16183940..16203385)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (16910043..16929465)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables retinal dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2-aminomuconic semialdehyde dehydrogenase

Names: aldehyde dehydrogenase family 8 member A1

NP_001178017.2

EC 1.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191088.2 → NP_001178017.2 2-aminomuconic semialdehyde dehydrogenase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZXY4

Related

ENSRNOP00000020015.4, ENSRNOT00000020015.6

Conserved Domains (1) summary

cd07093
Location:27 → 485

ALDH_F8_HMSADH; Human aldehyde dehydrogenase family 8 member A1-like