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    Aatk apoptosis-associated tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 11302, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Aatkprovided by MGI
    Official Full Name
    apoptosis-associated tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:1197518
    See related
    Ensembl:ENSMUSG00000025375 AllianceGenome:MGI:1197518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AATYK; aatyk1; mKIAA0641
    Summary
    Enables protein tyrosine kinase activity. Acts upstream of or within several processes, including Rab protein signal transduction; nervous system development; and peptidyl-tyrosine autophosphorylation. Located in several cellular components, including axonal growth cone; perinuclear region of cytoplasm; and recycling endosome. Is expressed in brain. Orthologous to human AATK (apoptosis associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 51.8), cortex adult (RPKM 38.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 83.96 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119898137..119938009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120007311..120047183, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31337 Neighboring gene STARR-positive B cell enhancer ABC_E2379 Neighboring gene predicted gene 11767 Neighboring gene predicted gene, 57802 Neighboring gene brain-specific angiogenesis inhibitor 1-associated protein 2 Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene centrosomal protein 131 Neighboring gene STARR-positive B cell enhancer ABC_E4021 Neighboring gene STARR-positive B cell enhancer ABC_E206 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hyperactive and impulsive behaviors of LMTK1 knockout mice. Takahashi M, et al. Sci Rep, 2020 Sep 22. PMID 32963255, Free PMC Article
    2. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. Ding LY, et al. Clin Epigenetics, 2020 Jun 17. PMID 32552862, Free PMC Article
    3. Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation. Wei R, et al. J Biochem, 2020 Jul 1. PMID 32044995
    4. Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma. Ma S, et al. Lab Invest, 2014 Apr. PMID 24589855
    5. Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation. Gagnon KB, et al. Am J Physiol Cell Physiol, 2007 May. PMID 17267545

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer.
      Title: Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer.
    2. Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation.
      Title: Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation.
    3. The results showed that AATYK knockdown inhibited Oligodendrocytes differentiation and the expression of myelin genes in vitro.
      Title: AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.
    4. LMTK1 negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking.
      Title: LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.
    5. Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons.
      Title: LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.
    6. results suggest a possibility that AATYK1A plays a role in early to recycling endosomes and its function is regulated by phosphorylation with Cdk5 or Src-family kinases
      Title: Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.
    7. Expression of AATYK mRNA and protein increased during postnatal brain development. In immature granule cells, overexpression of AATYK promoted neurite outgrowth; a tyrosine kinase-defective mutant significantly inhibited it.
      Title: Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain.
    8. AATYK1 indirectly inhibits the SPAK/WNK4 activation of the Na-K-2Cl cotransporter by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase.
      Title: Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation.
    9. phosphorylation states of AATYK are closely related to the high potassium-induced survival and low potassium-induced apoptosis of cerebellar granule cells
      Title: Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase LMTK1
    Names
    apoptosis-associated tyrosine kinase 1B
    brain apoptosis-associated tyrosine kinase
    lemur tyrosine kinase 1
    NP_001185714.1
    NP_001185716.1
    NP_001364432.1
    NP_001389718.1
    NP_031403.2
    XP_006532054.1
    XP_006532055.1
    XP_006532056.1
    XP_006532057.1
    XP_036012124.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198785.1 → NP_001185714.1  serine/threonine-protein kinase LMTK1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an in-frame upstream start codon compared to variant 1. This variant encodes a protein (isoform 2) with a longer N-terminus than isoform 1.
      Source sequence(s)
      AB288871, BC042837, BC080846
      Consensus CDS
      CCDS56826.1
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      UniProtKB/TrEMBL
      B1AZF3
      Related
      ENSMUSP00000067181.4, ENSMUST00000064307.10
      Conserved Domains (3) summary
      smart00221
      Location:138 → 405
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:137 → 407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:828 → 880
      DUF3676; Protein of unknown function (DUF3676)

    2. NM_001198787.1 → NP_001185716.1  serine/threonine-protein kinase LMTK1 isoform 1

      See identical proteins and their annotated locations for NP_001185716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant, and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK036705, BC080846
      Consensus CDS
      CCDS25725.1
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      UniProtKB/TrEMBL
      B1AZF9
      Related
      ENSMUSP00000099308.2, ENSMUST00000103019.2
      Conserved Domains (3) summary
      smart00221
      Location:81 → 348
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:80 → 350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:771 → 823
      DUF3676; Protein of unknown function (DUF3676)

    3. NM_001377503.1 → NP_001364432.1  serine/threonine-protein kinase LMTK1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL953913
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:473 → 904
      PHA03307; transcriptional regulator ICP4; Provisional
      cl21453
      Location:1 → 230
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001402789.1 → NP_001389718.1  serine/threonine-protein kinase LMTK1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL953913

    5. NM_007377.4 → NP_031403.2  serine/threonine-protein kinase LMTK1 isoform 1

      See identical proteins and their annotated locations for NP_031403.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      BC042837, BC080846
      Consensus CDS
      CCDS25725.1
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      UniProtKB/TrEMBL
      B1AZF9
      Related
      ENSMUSP00000099309.2, ENSMUST00000103020.8
      Conserved Domains (3) summary
      smart00221
      Location:81 → 348
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:80 → 350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:771 → 823
      DUF3676; Protein of unknown function (DUF3676)

    RNA

    1. NR_165305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913

    2. NR_165306.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913

    3. NR_175298.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119898137..119938009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531991.3 → XP_006532054.1  serine/threonine-protein kinase LMTK1 isoform X1

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:650 → 1081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:137 → 407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

    2. XM_006531993.3 → XP_006532056.1  serine/threonine-protein kinase LMTK1 isoform X4

      See identical proteins and their annotated locations for XP_006532056.1

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Related
      ENSMUST00000150730.8
      Conserved Domains (2) summary
      PHA03307
      Location:593 → 1024
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:80 → 350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

    3. XM_006531994.4 → XP_006532057.1  serine/threonine-protein kinase LMTK1 isoform X4

      See identical proteins and their annotated locations for XP_006532057.1

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:593 → 1024
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:80 → 350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

    4. XM_006531992.5 → XP_006532055.1  serine/threonine-protein kinase LMTK1 isoform X2

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:601 → 1032
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:88 → 358
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

    5. XM_036156231.1 → XP_036012124.1  serine/threonine-protein kinase LMTK1 isoform X5

      Related
      ENSMUST00000142959.2
      Conserved Domains (1) summary
      PHA03307
      Location:240 → 671
      PHA03307; transcriptional regulator ICP4; Provisional

    RNA

    1. XR_003949229.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YE4.1 GenPept UniProtKB/Swiss-Prot:Q80YE4

    Gene LinkOut

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