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    Zfp148 zinc finger protein 148 [ Mus musculus (house mouse) ]

    Gene ID: 22661, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfp148provided by MGI
    Official Full Name
    zinc finger protein 148provided by MGI
    Primary source
    MGI:MGI:1332234
    See related
    Ensembl:ENSMUSG00000022811 AllianceGenome:MGI:1332234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BERF-1; BFCOL1; ZBP-89; Znf148; 2210405J08Rik
    Summary
    Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within gamete generation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; genitourinary system; gut; and liver and biliary system. Orthologous to human ZNF148 (zinc finger protein 148). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.4), cortex adult (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B3; 16 23.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33201145..33324273)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33380775..33503903)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8629 Neighboring gene sorting nexin 4 Neighboring gene STARR-seq mESC enhancer starr_40689 Neighboring gene STARR-seq mESC enhancer starr_40691 Neighboring gene STARR-seq mESC enhancer starr_40692 Neighboring gene RIKEN cDNA 1700007L15 gene Neighboring gene STARR-seq mESC enhancer starr_40693 Neighboring gene STARR-seq mESC enhancer starr_40697 Neighboring gene STARR-seq mESC enhancer starr_40698 Neighboring gene STARR-seq mESC enhancer starr_40700 Neighboring gene solute carrier family 12 (potassium/chloride transporters), member 8 Neighboring gene STARR-seq mESC enhancer starr_40702 Neighboring gene STARR-positive B cell enhancer ABC_E5537 Neighboring gene STARR-seq mESC enhancer starr_40703 Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E11611

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses. Emfinger CH, et al. JCI Insight, 2022 May 23. PMID 35603790, Free PMC Article
    2. Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Li X, et al. Stem Cells, 2014 Mar. PMID 24549639, Free PMC Article
    3. The transcriptional repressor ZBP-89 and the lack of Sp1/Sp3, c-Jun and Stat3 are important for the down-regulation of the vimentin gene during C2C12 myogenesis. Salmon M, et al. Differentiation, 2009 Jun. PMID 19505630, Free PMC Article
    4. Conserved structure and promoter sequence similarity in the mouse and human genes encoding the zinc finger factor BERF-1/BFCOL1/ZBP-89. Feo S, et al. Biochem Biophys Res Commun, 2001 Apr 27. PMID 11322790
    5. Negative regulation of beta enolase gene transcription in embryonic muscle is dependent upon a zinc finger factor that binds to the G-rich box within the muscle-specific enhancer. Passantino R, et al. J Biol Chem, 1998 Jan 2. PMID 9417107

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp281 and Zfp148 control CD4[+] T cell thymic development and TH2 functions.
      Title: Zfp281 and Zfp148 control CD4(+) T cell thymic development and T(H)2 functions.
    2. Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in regulating HaCaT cell proliferation, migration and apoptosis.
      Title: Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in regulating HaCaT cell proliferation, migration and apoptosis.
    3. beta Cell-specific deletion of Zfp148 improves nutrient-stimulated beta cell Ca2+ responses.
      Title: β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses.
    4. Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway.
      Title: Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway.
    5. ZFP148 is important in the regulation of proliferation, smooth muscle gene downregulation, and apoptosis in aneurysm development.
      Title: ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation.
    6. Data indicate zinc finger protein 148 (ZFP148) as a transcription factor that differentially binds to the zinc finger protein 30 protein (Zfp30) promoter region harboring rs51434084.
      Title: Differential Regulation of Zfp30 Expression in Murine Airway Epithelia Through Altered Binding of ZFP148 to rs51434084.
    7. The results suggest that Zfp148 controls the fate of newly transformed intestinal tumor cells by repressing p53 and that targeting Zfp148 might be useful in the treatment of colorectal cancer.
      Title: Targeting Zfp148 activates p53 and reduces tumor initiation in the gut.
    8. Zfp148 deficiency increases p53 activity and protects against atherosclerosis by causing proliferation arrest of lesional macrophages.
      Title: Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53.
    9. These data identify an important role for ZBP-89 in regulating stress hematopoiesis in adult mouse bone marrow.
      Title: Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.
    10. Results indicate that Zfp148-deficient mice generate normal mature hematopoietic populations.
      Title: Zinc finger protein 148 is dispensable for primitive and definitive hematopoiesis in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 148
    Names
    G-rich box-binding protein
    beta enolase repressor factor 1
    transcription factor BFCOL1
    transcription factor ZBP-89
    zinc finger DNA-binding protein 89

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358569.1 → NP_001345498.1  zinc finger protein 148

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC122247, AC127412
      Consensus CDS
      CCDS28130.1
      UniProtKB/Swiss-Prot
      P97475, Q61624
      UniProtKB/TrEMBL
      Q3UJ69, Q548L0
      Related
      ENSMUSP00000087106.7, ENSMUST00000089677.7
      Conserved Domains (3) summary
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171 → 193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214 → 238
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001358570.1 → NP_001345499.1  zinc finger protein 148

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC122247, AC127412
      Consensus CDS
      CCDS28130.1
      UniProtKB/Swiss-Prot
      P97475, Q61624
      UniProtKB/TrEMBL
      Q3UJ69, Q548L0
      Conserved Domains (3) summary
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171 → 193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214 → 238
      zf-H2C2_2; Zinc-finger double domain

    3. NM_011749.4 → NP_035879.1  zinc finger protein 148

      See identical proteins and their annotated locations for NP_035879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC127412, AK146591, CJ129103, CK634070
      Consensus CDS
      CCDS28130.1
      UniProtKB/Swiss-Prot
      P97475, Q61624
      UniProtKB/TrEMBL
      Q3UJ69, Q548L0
      Related
      ENSMUSP00000126338.2, ENSMUST00000165418.9
      Conserved Domains (3) summary
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171 → 193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214 → 238
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33201145..33324273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522103.5 → XP_006522166.1  zinc finger protein 148 isoform X3

      UniProtKB/TrEMBL
      A0A338P6K3, Q3UJ69
      Related
      ENSMUSP00000156030.2, ENSMUST00000232023.2
      Conserved Domains (3) summary
      sd00017
      Location:131 → 151
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:129 → 151
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:172 → 196
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006522098.4 → XP_006522161.1  zinc finger protein 148 isoform X1

      See identical proteins and their annotated locations for XP_006522161.1

      UniProtKB/TrEMBL
      Q3UJ69
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    3. XM_036159911.1 → XP_036015804.1  zinc finger protein 148 isoform X2

      UniProtKB/Swiss-Prot
      P97475, Q61624
      UniProtKB/TrEMBL
      Q3UJ69, Q548L0
      Conserved Domains (3) summary
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171 → 193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214 → 238
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006522099.5 → XP_006522162.1  zinc finger protein 148 isoform X1

      See identical proteins and their annotated locations for XP_006522162.1

      UniProtKB/TrEMBL
      Q3UJ69
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011245888.3 → XP_011244190.1  zinc finger protein 148 isoform X1

      See identical proteins and their annotated locations for XP_011244190.1

      UniProtKB/TrEMBL
      Q3UJ69
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    6. XM_006522100.5 → XP_006522163.1  zinc finger protein 148 isoform X1

      See identical proteins and their annotated locations for XP_006522163.1

      UniProtKB/TrEMBL
      Q3UJ69
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    7. XM_006522101.5 → XP_006522164.1  zinc finger protein 148 isoform X1

      See identical proteins and their annotated locations for XP_006522164.1

      UniProtKB/TrEMBL
      Q3UJ69
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61624.2 GenPept UniProtKB/Swiss-Prot:Q61624

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