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    GPR171 G protein-coupled receptor 171 [ Homo sapiens (human) ]

    Gene ID: 29909, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR171provided by HGNC
    Official Full Name
    G protein-coupled receptor 171provided by HGNC
    Primary source
    HGNC:HGNC:30057
    See related
    Ensembl:ENSG00000174946 MIM:618925; AllianceGenome:HGNC:30057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H963
    Summary
    Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within negative regulation of myeloid cell differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in appendix (RPKM 5.9), lymph node (RPKM 4.6) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q25.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151197754..151203216, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (153948805..153954267, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150915619..150921003, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CLRN1 antisense RNA 1 Neighboring gene uncharacterized LOC124909448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14822 Neighboring gene Sharpr-MPRA regulatory region 19 Neighboring gene mediator complex subunit 12L Neighboring gene RNA, 5S ribosomal pseudogene 145 Neighboring gene Sharpr-MPRA regulatory region 7583 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959259-150959858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959859-150960456 Neighboring gene purinergic receptor P2Y14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20700 Neighboring gene Sharpr-MPRA regulatory region 3159 Neighboring gene SET pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:151033994-151035193 Neighboring gene G protein-coupled receptor 87

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPR171 expression enhances proliferation and metastasis of lung cancer cells. Dho SH, et al. Oncotarget, 2016 Feb 16. PMID 26760963, Free PMC Article
    2. A genetic selection for isolating cDNAs encoding secreted proteins. Jacobs KA, et al. Gene, 1997 Oct 1. PMID 9370294
    3. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Gomes I, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043826, Free PMC Article
    4. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. Joensuu T, et al. Am J Hum Genet, 2001 Oct. PMID 11524702, Free PMC Article
    5. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Macaulay IC, et al. Blood, 2007 Apr 15. PMID 17192395, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High GPR171 expression enhances proliferation and metastasis of lung cancer.
      Title: GPR171 expression enhances proliferation and metastasis of lung cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neuropeptide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 171
    Names
    F730001G15Rik
    G-protein coupled receptor H963
    platelet activating receptor homolog
    probable G-protein coupled receptor 171

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013308.4 → NP_037440.3  G-protein coupled receptor 171

      See identical proteins and their annotated locations for NP_037440.3

      Status: VALIDATED

      Source sequence(s)
      AA353758, AC078816, AF002986, BC036815
      Consensus CDS
      CCDS3155.1
      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06
      Related
      ENSP00000308479.5, ENST00000309180.6
      Conserved Domains (1) summary
      cd15167
      Location:15 → 296
      7tmA_GPR171; orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      151197754..151203216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448056.1 → XP_047304012.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06

    2. XM_005247402.4 → XP_005247459.1  G-protein coupled receptor 171 isoform X1

      See identical proteins and their annotated locations for XP_005247459.1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06
      Related
      ENSP00000482588.1, ENST00000617554.1
      Conserved Domains (1) summary
      cd15167
      Location:15 → 296
      7tmA_GPR171; orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_047448054.1 → XP_047304010.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06

    4. XM_005247403.4 → XP_005247460.1  G-protein coupled receptor 171 isoform X1

      See identical proteins and their annotated locations for XP_005247460.1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06
      Conserved Domains (1) summary
      cd15167
      Location:15 → 296
      7tmA_GPR171; orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_047448055.1 → XP_047304011.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      153948805..153954267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346389.1 → XP_054202364.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06

    2. XM_054346385.1 → XP_054202360.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06

    3. XM_054346386.1 → XP_054202361.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06

    4. XM_054346388.1 → XP_054202363.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06

    5. XM_054346387.1 → XP_054202362.1  G-protein coupled receptor 171 isoform X1

      UniProtKB/Swiss-Prot
      D3DNJ4, O14626, Q8IV06
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14626.1 GenPept UniProtKB/Swiss-Prot:O14626

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