Cltrn collectrin, amino acid transport regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cltrnprovided by RGD
Official Full Name: collectrin, amino acid transport regulatorprovided by RGD
Primary source: RGD:708489
See related: Ensembl:ENSRNOG00000003960 AllianceGenome:RGD:708489
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nx17; NX-17; Tmem27; collectrin
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in SNARE complex assembly; positive regulation of L-proline import across plasma membrane; and regulation of transmembrane transporter activity. Predicted to act upstream of with a positive effect on calcium-ion regulated exocytosis and insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in brush border membrane and cytoplasm. Predicted to be active in plasma membrane. Orthologous to human CLTRN (collectrin, amino acid transport regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 6608.2) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (33993825..34027124, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30361967..30395264, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (32118082..32153687, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectrin expression in the retinal pigment epithelium was significantly modulated during aging.
Title: Age-related changes in the retinal pigment epithelium (RPE).
Upregulation of collectrin by high NaCl independent of aldosterone functionally links to the trafficking of apical membrane proteins via the SNARE complex, and collectrin may be responsible for the sodium retention in salt-sensitive hypertension.
Title: Collectrin is involved in the development of salt-sensitive hypertension by facilitating the membrane trafficking of apical membrane proteins via interaction with soluble N-ethylmaleiamide-sensitive factor attachment protein receptor complex.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SNARE complex assembly	IEA Inferred from Electronic Annotation more info
involved_in SNARE complex assembly	ISO Inferred from Sequence Orthology more info
involved_in calcium-ion regulated exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-proline import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of L-proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of amino acid transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: collectrin

Names: kidney-specific membrane protein; transmembrane protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020976.2 → NP_066125.2 collectrin precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6AYY2, Q9ESG3

UniProtKB/TrEMBL

A0A8L2Q282, A6K2L7

Related

ENSRNOP00000005348.4, ENSRNOT00000005348.6

Conserved Domains (1) summary

pfam16959
Location:24 → 171

Collectrin; Renal amino acid transporter