Lhb luteinizing hormone subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lhbprovided by RGD
Official Full Name: luteinizing hormone subunit betaprovided by RGD
Primary source: RGD:3006
See related: Ensembl:ENSRNOG00000063034 AllianceGenome:RGD:3006
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within luteinizing hormone signaling pathway involved in ovarian follicle development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Orthologous to several human genes including LHB (luteinizing hormone subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 54.0), Lung (RPKM 27.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105037457..105038446)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95898269..95901973)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101409992..101413725)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orchestrated Egr1 and Pitx1 activities depending on specific central and peripheral regulatory inputs could be responsible for physiologically variable Lhb gene promoter activation in vivo.
Title: In vivo oestrogenic modulation of Egr1 and Pitx1 gene expression in female rat pituitary gland.
GnRH stimulates AMPK, and AMPK inhibition suppresses GnRH-stimulated LHbeta transcription.
Title: AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription.
data suggest that the molecular decision for LHbeta subunit to enter the regulated secretory pathway is a pre-Golgi event controlled by the C-terminal heptapeptide.
Title: A novel carboxyl-terminal heptapeptide initiates the regulated secretion of LH from unique sub-domains of the ER.
increased LH concentration induces production of incomplete LHR transcripts in hippocampal cells and decreases immature LHR at the protein level
Title: Regulation of luteinizing hormone receptor in hippocampal neurons following different long-lasting treatments of castrated adult rats.
Data suggest that LH beta subunit expression (and FSH beta subunit expression) is regulated by DUSP1 expression (specifically in response to high-frequency GnRH pulses); this effect may occur in association with MAPK3/1 phosphorylation.
Title: Induction of dual-specificity phosphatase 1 (DUSP1) by pulsatile gonadotropin-releasing hormone stimulation: role for gonadotropin subunit expression in mouse pituitary LbetaT2 cells.
Complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes.
Title: Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression.
LHbeta promoter activity is further regulated by the orphan nuclear receptors, chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and COUP-TFII).
Title: The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.
data suggest that LHbeta G1502A polymorphism may be involved in the predisposition to infertility and minimal/mild endometriosis-associated infertility, although endometriosis might be only a coincidental finding along with infertility.
Title: Luteinizing hormone beta-subunit gene (LHbeta) polymorphism in infertility and endometriosis-associated infertility.
Exaggerated release of gonadotropins in rats primed with GnRH antagonist and treated with GnRH agonist was due to an increase in releasable gonadotropin pools coupled with a reduction in GnRH-R, but receptor function was preserved.
Title: The mechanism responsible for the supraphysiologic gonadotropin surge in females treated with gonadotropin-releasing hormone (GnRH) agonist and primed with GnRH antagonist.
These results suggest that the expression of LHbeta in the ovary is regulated by locally produced GnRH and by FSH from either the ovary or the pituitary.
Title: Hormonal regulation of GnRH and LHbeta mRNA expression in cultured rat granulosa cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within luteinizing hormone signaling pathway involved in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in organic cyclic compound metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lutropin subunit beta

Names: LH-B; LSH-B; LSH-beta; Luteinizing hormone (lutropin) subunit beta; luteinizing hormone beta polypeptide; luteinizing hormone beta subunit; lutropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.