Aprt adenine phosphoribosyl transferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aprtprovided by RGD
Official Full Name: adenine phosphoribosyl transferaseprovided by RGD
Primary source: RGD:1307758
See related: Ensembl:ENSRNOG00000014405 AllianceGenome:RGD:1307758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables AMP binding activity. Involved in cellular response to insulin stimulus and lactation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 571.1), Lung (RPKM 480.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (67534737..67537027, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (50626201..50628491, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55387288..55389256, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127914 (e-PCR)
- UniSTS:211224

Aprt (e-PCR), detects polymorphism
- UniSTS:141116

RH94458 (e-PCR)
- UniSTS:119706

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables AMP binding	IDA Inferred from Direct Assay more info	PubMed
enables AMP binding	IEA Inferred from Electronic Annotation more info
enables AMP binding	ISO Inferred from Sequence Orthology more info
enables adenine binding	IBA Inferred from Biological aspect of Ancestor more info
enables adenine binding	IEA Inferred from Electronic Annotation more info
enables adenine binding	ISO Inferred from Sequence Orthology more info
enables adenine phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables adenine phosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables adenine phosphoribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in AMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within AMP salvage	ISO Inferred from Sequence Orthology more info
involved_in AMP salvage	ISO Inferred from Sequence Orthology more info
involved_in GMP salvage	IEA Inferred from Electronic Annotation more info
involved_in GMP salvage	ISO Inferred from Sequence Orthology more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in IMP salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in adenine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenine salvage	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in grooming behavior	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within grooming behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in lactation	IDA Inferred from Direct Assay more info	PubMed
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine ribonucleoside salvage	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenine phosphoribosyltransferase

NP_001013079.1

EC 2.4.2.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.