Gsn gelsolin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gsnprovided by RGD
Official Full Name: gelsolinprovided by RGD
Primary source: RGD:1303089
See related: Ensembl:ENSRNOG00000018991 AllianceGenome:RGD:1303089
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables actin binding activity. Involved in several processes, including cellular response to cadmium ion; oligodendrocyte development; and phosphatidylinositol-mediated signaling. Located in several cellular components, including myelin sheath; perinuclear region of cytoplasm; and ruffle. Part of protein-containing complex. Biomarker of hypothyroidism and lung disease. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 4957.5), Heart (RPKM 3919.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (38982605..39035849)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (18585166..18638404)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (14456106..14508922)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS).
Title: LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
hypoxia or GSN overexpression induces HIF-1alpha expression and reduces the expression of survival markers p-Akt and Bcl-2 in H9c2 cardiomyoblast cells
Title: Hypoxia Augments Increased HIF-1α and Reduced Survival Protein p-Akt in Gelsolin (GSN)-Dependent Cardiomyoblast Cell Apoptosis.
These findings suggested a potential role of GSN in the pathophysiology of the brain at the early stage of subarachnoid hemorrhage.
Title: Expression of Cytoplasmic Gelsolin in Rat Brain After Experimental Subarachnoid Hemorrhage.
our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex
Title: The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.
It was concluded that cytoskeletal effects of Cd in mesangial cells are partially mediated by Cd-dependent activation of CaMK-IIdelta, binding of CaMK-IIdelta and gelsolin to actin filaments, and cleavage of gelsolin.
Title: Involvement of CaMK-IIδ and gelsolin in Cd(2+) -dependent cytoskeletal effects in mesangial cells.
We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas disease
Title: Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
This report indicates that structural differences between plasma and cytoplasmic gelsolin do not play a key role in their complex formation with Abeta.
Title: Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein.
Gelsolin is found at high levels (comparable to plasma) in mesenteric lymph. Following hemorrhagic shock, gelsolin levels decrease significantly, possibly due to consumption by the actin scavenging system.
Title: Gelsolin is depleted in post-shock mesenteric lymph.
Results suggest that the spatiotemporal upregulation of gelsolin in the hippocampus is induced by entorhinal deafferentation.
Title: Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation.
gelsolin modulates the actin cytoskeleton and regulates vacuolar H+-ATPase recycling
Title: Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498432 (e-PCR)
- UniSTS:498432

Gsn (e-PCR), detects polymorphism
- UniSTS:498432

RH128257 (e-PCR)
- UniSTS:211565

Gsn (e-PCR), detects polymorphism
- UniSTS:474748

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables myosin II binding	IEA Inferred from Electronic Annotation more info
enables myosin II binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in actin filament depolymerization	IEA Inferred from Electronic Annotation more info
involved_in actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament severing	IEA Inferred from Electronic Annotation more info
involved_in actin filament severing	ISO Inferred from Sequence Orthology more info
involved_in actin filament severing	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein processing in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein processing in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of T cell polarity	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of plasma membrane raft polarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of plasma membrane raft polarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	IEA Inferred from Electronic Annotation more info
involved_in relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in renal protein absorption	IEA Inferred from Electronic Annotation more info
involved_in renal protein absorption	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to folic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in sequestering of actin monomers	IEA Inferred from Electronic Annotation more info
involved_in sequestering of actin monomers	ISO Inferred from Sequence Orthology more info
involved_in striated muscle atrophy	IEA Inferred from Electronic Annotation more info
involved_in striated muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cap	IEA Inferred from Electronic Annotation more info
located_in actin cap	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in apical ectoplasmic specialization	IDA Inferred from Direct Assay more info	PubMed
located_in basal ectoplasmic specialization	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in glial filament	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in podosome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IEA Inferred from Electronic Annotation more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gelsolin

Names: ADF; actin-depolymerizing factor; brevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004080.1 → NP_001004080.1 gelsolin precursor

See identical proteins and their annotated locations for NP_001004080.1

Status: PROVISIONAL

Source sequence(s)

BC079472

UniProtKB/Swiss-Prot

Q68FP1

UniProtKB/TrEMBL

A6JUE8

Related

ENSRNOP00000025857.5, ENSRNOT00000025857.6

Conserved Domains (6) summary

cd11288
Location:559 → 647

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:184 → 273

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:57 → 169

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:664 → 762

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:296 → 393

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:437 → 537

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

38982605..39035849

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591662.3 → XP_017447151.1 gelsolin isoform X1

UniProtKB/TrEMBL

A0A8I5ZZX4, A6JUE9

Related

ENSRNOP00000084576.1

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:258 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
XM_063283523.1 → XP_063139593.1 gelsolin isoform X1

UniProtKB/TrEMBL

A0A8I5ZZX4
XM_006234040.4 → XP_006234102.1 gelsolin isoform X2

UniProtKB/TrEMBL

A6JUE9

Related

ENSRNOP00000075631.2

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
XM_039104784.2 → XP_038960712.1 gelsolin isoform X2

UniProtKB/TrEMBL

A6JUE9

Related

ENSRNOP00000088362.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
XM_063283524.1 → XP_063139594.1 gelsolin isoform X1

UniProtKB/TrEMBL

A0A8I5ZZX4