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    Coq10b coenzyme Q10B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301416, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Coq10bprovided by RGD
    Official Full Name
    coenzyme Q10Bprovided by RGD
    Primary source
    RGD:1359509
    See related
    Ensembl:ENSRNOG00000014456 AllianceGenome:RGD:1359509
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1359509
    Summary
    Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human COQ10B (coenzyme Q10B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 404.2), Kidney (RPKM 164.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (64048168..64068082)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (56553751..56573671)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (61655963..61675880)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L11, pseudogene 6 Neighboring gene splicing factor 3b, subunit 1 Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene Neighboring gene MOB family member 4, phocein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension. Kucharská J, et al. Physiol Res, 2007. PMID 17824807
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Administration of simvastatin under the condition of nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the heart and skeletal muscle.
      Title: Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109115

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme Q-binding protein COQ10 homolog B, mitochondrial
    Names
    coenzyme Q10 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009671.1 → NP_001009671.1  coenzyme Q-binding protein COQ10 homolog B, mitochondrial

      See identical proteins and their annotated locations for NP_001009671.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088273
      UniProtKB/Swiss-Prot
      Q5I0I9
      UniProtKB/TrEMBL
      A6IP05
      Related
      ENSRNOP00000050509.4, ENSRNOT00000040461.4
      Conserved Domains (1) summary
      cd07813
      Location:82 → 220
      COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      64048168..64068082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0I9.2 GenPept UniProtKB/Swiss-Prot:Q5I0I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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