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    Baz2b bromodomain adjacent to zinc finger domain, 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317627, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Baz2bprovided by RGD
    Official Full Name
    bromodomain adjacent to zinc finger domain, 2Bprovided by RGD
    Primary source
    RGD:1309801
    See related
    Ensembl:ENSRNOG00000056984 AllianceGenome:RGD:1309801
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to act upstream of or within modulation of age-related behavioral decline. Predicted to be located in nucleus. Orthologous to human BAZ2B (bromodomain adjacent to zinc finger domain 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 138.7), Kidney (RPKM 118.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q21
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64792984..65034547, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44384282..44681619, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45968845..46286915, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene uncharacterized LOC134486097 Neighboring gene uncharacterized LOC108350580 Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene ADP-ribosylation factor 4, pseudogene 1 Neighboring gene uncharacterized LOC120101908 Neighboring gene RNA, U6 small nuclear 22 Neighboring gene membrane associated ring-CH-type finger 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain adjacent to zinc finger domain protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108260.1 → NP_001101730.1  bromodomain adjacent to zinc finger domain protein 2B

      See identical proteins and their annotated locations for NP_001101730.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      A0A0G2K175, A0A0G2K535, A6JF71
      Related
      ENSRNOP00000071727.2, ENSRNOT00000081302.2
      Conserved Domains (7) summary
      cd05503
      Location:2088 → 2184
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1074 → 1137
      DDT; domain in different transcription and chromosome remodeling factors
      cd15630
      Location:1955 → 2003
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam13868
      Location:832 → 1047
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:1178 → 1218
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:1358 → 1390
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl00110
      Location:755 → 824
      MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      64792984..65034547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284041.1 → XP_063140111.1  bromodomain adjacent to zinc finger domain protein 2B isoform X26

    2. XM_063284024.1 → XP_063140094.1  bromodomain adjacent to zinc finger domain protein 2B isoform X15

    3. XM_063284046.1 → XP_063140116.1  bromodomain adjacent to zinc finger domain protein 2B isoform X31

    4. XM_063284011.1 → XP_063140081.1  bromodomain adjacent to zinc finger domain protein 2B isoform X6

    5. XM_063284045.1 → XP_063140115.1  bromodomain adjacent to zinc finger domain protein 2B isoform X30

    6. XM_063284009.1 → XP_063140079.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

    7. XM_063284040.1 → XP_063140110.1  bromodomain adjacent to zinc finger domain protein 2B isoform X25

    8. XM_063284038.1 → XP_063140108.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

    9. XM_063284022.1 → XP_063140092.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

    10. XM_063284036.1 → XP_063140106.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

    11. XM_063284033.1 → XP_063140103.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

    12. XM_063284018.1 → XP_063140088.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

    13. XM_063284030.1 → XP_063140100.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

    14. XM_063284047.1 → XP_063140117.1  bromodomain adjacent to zinc finger domain protein 2B isoform X32

    15. XM_063284005.1 → XP_063140075.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    16. XM_063284031.1 → XP_063140101.1  bromodomain adjacent to zinc finger domain protein 2B isoform X20

    17. XM_063284028.1 → XP_063140098.1  bromodomain adjacent to zinc finger domain protein 2B isoform X18

      UniProtKB/TrEMBL
      A0A8I6A6K9

    18. XM_039105324.2 → XP_038961252.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

      UniProtKB/TrEMBL
      A0A0G2K535
      Related
      ENSRNOP00000087832.1
      Conserved Domains (7) summary
      cd05503
      Location:1994 → 2090
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      PTZ00121
      Location:734 → 957
      PTZ00121; MAEBL; Provisional
      smart00571
      Location:980 → 1043
      DDT; domain in different transcription and chromosome remodeling factors
      cd15630
      Location:1861 → 1909
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam15612
      Location:1084 → 1124
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:1264 → 1296
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl00110
      Location:659 → 728
      MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

    19. XM_063284014.1 → XP_063140084.1  bromodomain adjacent to zinc finger domain protein 2B isoform X9

    20. XM_063284013.1 → XP_063140083.1  bromodomain adjacent to zinc finger domain protein 2B isoform X8

    21. XM_063284012.1 → XP_063140082.1  bromodomain adjacent to zinc finger domain protein 2B isoform X7

    22. XM_063284017.1 → XP_063140087.1  bromodomain adjacent to zinc finger domain protein 2B isoform X12

    23. XM_063284008.1 → XP_063140078.1  bromodomain adjacent to zinc finger domain protein 2B isoform X4

    24. XM_063284016.1 → XP_063140086.1  bromodomain adjacent to zinc finger domain protein 2B isoform X11

    25. XM_063284004.1 → XP_063140074.1  bromodomain adjacent to zinc finger domain protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A0G2K175, A6JF71

    26. XM_063284032.1 → XP_063140102.1  bromodomain adjacent to zinc finger domain protein 2B isoform X21

    27. XM_063284015.1 → XP_063140085.1  bromodomain adjacent to zinc finger domain protein 2B isoform X10

    28. XM_063283999.1 → XP_063140069.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

    29. XM_063284025.1 → XP_063140095.1  bromodomain adjacent to zinc finger domain protein 2B isoform X16

    30. XM_063284010.1 → XP_063140080.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

    31. XM_063284039.1 → XP_063140109.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

    32. XM_063284023.1 → XP_063140093.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

    33. XM_063284037.1 → XP_063140107.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

    34. XM_063284034.1 → XP_063140104.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

    35. XM_063284019.1 → XP_063140089.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

    36. XM_063284029.1 → XP_063140099.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

    37. XM_063284006.1 → XP_063140076.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    38. XM_063284026.1 → XP_063140096.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

    39. XM_063284000.1 → XP_063140070.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

    40. XM_063284021.1 → XP_063140091.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

    41. XM_063284002.1 → XP_063140072.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

    42. XM_063284020.1 → XP_063140090.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

    43. XM_063284001.1 → XP_063140071.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

    44. XM_063284035.1 → XP_063140105.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

    45. XM_063284007.1 → XP_063140077.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    46. XM_063284027.1 → XP_063140097.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

    47. XM_063284003.1 → XP_063140073.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

    48. XM_063284044.1 → XP_063140114.1  bromodomain adjacent to zinc finger domain protein 2B isoform X29

    49. XM_063284043.1 → XP_063140113.1  bromodomain adjacent to zinc finger domain protein 2B isoform X28

    50. XM_063284042.1 → XP_063140112.1  bromodomain adjacent to zinc finger domain protein 2B isoform X27

    Nucleotide Protein Strain
    Heading Accession and Version

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