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    Kash5 KASH domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308581, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Kash5provided by RGD
    Official Full Name
    KASH domain containing 5provided by RGD
    Primary source
    RGD:1561972
    See related
    Ensembl:ENSRNOG00000025378 AllianceGenome:RGD:1561972
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc155; RGD1561972; Ccdc155-ps1
    Summary
    Predicted to enable dynein complex binding activity and identical protein binding activity. Predicted to be involved in several processes, including cytoskeleton organization; homologous chromosome segregation; and spindle localization. Predicted to act upstream of or within double-strand break repair via homologous recombination; oogenesis; and spermatogenesis. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in chromosome; meiotic spindle pole; and nuclear outer membrane. Orthologous to human KASH5 (KASH domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 72.3), Muscle (RPKM 17.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kash5 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104805248..104827720, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95668918..95691353, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101180497..101203048, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene golgi-associated, olfactory signaling regulator Neighboring gene parathyroid hormone 2 Neighboring gene uncharacterized LOC134483103 Neighboring gene dickkopf like acrosomal protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes. Luo Y, et al. Sci Rep, 2016 Feb 4. PMID 26842404, Free PMC Article
    2. Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Lee CY, et al. Cell Rep, 2015 Apr 28. PMID 25892231, Free PMC Article
    3. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. Horn HF, et al. J Cell Biol, 2013 Sep 30. PMID 24062341, Free PMC Article
    4. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. Morimoto A, et al. J Cell Biol, 2012 Jul 23. PMID 22826121, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome localization to nuclear envelope involved in homologous chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromosome localization to nuclear envelope involved in homologous chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic telomere clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lateral element IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in meiotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in meiotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein KASH5
    Names
    coiled-coil domain containing 155, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104805248..104827720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278194.1 → XP_063134264.1  protein KASH5 isoform X2

    2. XM_063278191.1 → XP_063134261.1  protein KASH5 isoform X1

    3. XM_063278201.1 → XP_063134271.1  protein KASH5 isoform X4

    4. XM_063278198.1 → XP_063134268.1  protein KASH5 isoform X3

    5. XM_063278223.1 → XP_063134293.1  protein KASH5 isoform X8

    6. XM_063278212.1 → XP_063134282.1  protein KASH5 isoform X7

    7. XM_039094057.2 → XP_038949985.1  protein KASH5 isoform X6

      Conserved Domains (2) summary
      pfam14658
      Location:78 → 145
      EF-hand_9; EF-hand domain
      pfam14662
      Location:213 → 367
      KASH_CCD; Coiled-coil region of CCDC155 or KASH

    8. XM_006229199.5 → XP_006229261.1  protein KASH5 isoform X5

      See identical proteins and their annotated locations for XP_006229261.1

      UniProtKB/TrEMBL
      D3ZPX3
      Related
      ENSRNOP00000037916.7
      Conserved Domains (4) summary
      pfam14658
      Location:78 → 145
      EF-hand_9; EF-hand domain
      pfam14662
      Location:197 → 388
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam16046
      Location:237 → 313
      FAM76; FAM76 protein
      cl12013
      Location:223 → 385
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_005494382.2 RNA Sequence

    2. XR_005494387.2 RNA Sequence

    3. XR_005494386.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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