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    Sugct succinylCoA:glutarate-CoA transferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361253, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sugctprovided by RGD
    Official Full Name
    succinylCoA:glutarate-CoA transferaseprovided by RGD
    Primary source
    RGD:1308114
    See related
    Ensembl:ENSRNOG00000066247 AllianceGenome:RGD:1308114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308114
    Summary
    Predicted to enable succinate-hydroxymethylglutarate CoA-transferase activity. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia type 3. Orthologous to human SUGCT (succinyl-CoA:glutarate-CoA transferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 262.2), Liver (RPKM 90.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sugct in Genome Data Viewer
    Location:
    17q11-q12.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (52072012..52929852)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (47376392..48234362)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (49991314..51030950)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 13 Neighboring gene M-phase specific PLK1 interacting protein Neighboring gene macrophage migration inhibitory factor, pseudogene Neighboring gene uncharacterized LOC108348564

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA. Marlaire S, et al. J Inherit Metab Dis, 2014 Jan. PMID 23893049
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables succinate-hydroxymethylglutarate CoA-transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-hydroxymethylglutarate CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinate-hydroxymethylglutarate CoA-transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    succinate--hydroxymethylglutarate CoA-transferase
    Names
    caiB/baiF CoA-transferase family protein C7orf10 homolog
    NP_001014168.1
    XP_038951826.1
    XP_038951827.1
    XP_038951828.1
    XP_038951829.1
    XP_038951830.1
    XP_038951831.1
    XP_038951832.1
    XP_038951834.1
    XP_038951835.1
    XP_038951837.1
    XP_063132687.1
    XP_063132688.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014146.1 → NP_001014168.1  succinate--hydroxymethylglutarate CoA-transferase

      See identical proteins and their annotated locations for NP_001014168.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079348
      UniProtKB/Swiss-Prot
      F1LXJ6, Q68FU4
      Related
      ENSRNOP00000079174.1, ENSRNOT00000108763.1
      Conserved Domains (1) summary
      COG1804
      Location:34 → 430
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      52072012..52929852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095899.2 → XP_038951827.1  succinate--hydroxymethylglutarate CoA-transferase isoform X2

      Conserved Domains (1) summary
      pfam02515
      Location:39 → 374
      CoA_transf_3; CoA-transferase family III

    2. XM_039095902.2 → XP_038951830.1  succinate--hydroxymethylglutarate CoA-transferase isoform X4

      Conserved Domains (1) summary
      pfam02515
      Location:39 → 358
      CoA_transf_3; CoA-transferase family III

    3. XM_039095898.2 → XP_038951826.1  succinate--hydroxymethylglutarate CoA-transferase isoform X1

      Conserved Domains (1) summary
      COG1804
      Location:34 → 413
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    4. XM_039095903.2 → XP_038951831.1  succinate--hydroxymethylglutarate CoA-transferase isoform X5

      Conserved Domains (1) summary
      COG1804
      Location:34 → 344
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    5. XM_063276617.1 → XP_063132687.1  succinate--hydroxymethylglutarate CoA-transferase isoform X6

    6. XM_039095901.2 → XP_038951829.1  succinate--hydroxymethylglutarate CoA-transferase isoform X3

      Conserved Domains (1) summary
      COG1804
      Location:1 → 395
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    7. XM_039095900.2 → XP_038951828.1  succinate--hydroxymethylglutarate CoA-transferase isoform X3

      Conserved Domains (1) summary
      COG1804
      Location:1 → 395
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    8. XM_063276618.1 → XP_063132688.1  succinate--hydroxymethylglutarate CoA-transferase isoform X8

    9. XM_039095904.1 → XP_038951832.1  succinate--hydroxymethylglutarate CoA-transferase isoform X7

      Conserved Domains (1) summary
      COG1804
      Location:30 → 303
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    10. XM_039095906.1 → XP_038951834.1  succinate--hydroxymethylglutarate CoA-transferase isoform X8

      Conserved Domains (1) summary
      COG1804
      Location:1 → 292
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    11. XM_039095907.2 → XP_038951835.1  succinate--hydroxymethylglutarate CoA-transferase isoform X8

      Conserved Domains (1) summary
      COG1804
      Location:1 → 292
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    12. XM_039095909.2 → XP_038951837.1  succinate--hydroxymethylglutarate CoA-transferase isoform X9

      Conserved Domains (1) summary
      COG1804
      Location:1 → 264
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FU4.1 GenPept UniProtKB/Swiss-Prot:Q68FU4

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