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    Atp11c ATPase phospholipid transporting 11C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317599, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Atp11cprovided by RGD
    Official Full Name
    ATPase phospholipid transporting 11Cprovided by RGD
    Primary source
    RGD:1564481
    See related
    Ensembl:ENSRNOG00000003472 AllianceGenome:RGD:1564481
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp11c-ps1; RGD1564481
    Summary
    Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Predicted to be involved in phospholipid translocation; positive regulation of B cell differentiation; and pre-B cell differentiation. Predicted to be integral component of plasma membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia. Orthologous to human ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 422.7), Lung (RPKM 77.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq36
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (143600763..143788407, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (138564459..138752116, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (143340712..143525588, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene coagulation factor IX Neighboring gene MCF.2 cell line derived transforming sequence Neighboring gene microRNA 3589 Neighboring gene microRNA 505 Neighboring gene similar to human chromosome X open reading frame 66 Neighboring gene HUWE1 associated protein modifying stress responses 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Yabas M, et al. Nat Immunol, 2011 May. PMID 21423173, Free PMC Article
    2. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
    3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pre-B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IG
    Names
    ATPase, class VI, type 11C, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      143600763..143788407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100444.2 → XP_038956372.1  phospholipid-transporting ATPase IG isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV31, A0A8I5ZVG5
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:862 → 1090
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    2. XM_039100447.2 → XP_038956375.1  phospholipid-transporting ATPase IG isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV31, A0A8I5ZVG5
      Related
      ENSRNOP00000048676.5
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:862 → 1090
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    3. XM_039100445.2 → XP_038956373.1  phospholipid-transporting ATPase IG isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV31, A0A8I5ZVG5
      Related
      ENSRNOP00000083253.1
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:862 → 1090
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    4. XM_039100446.2 → XP_038956374.1  phospholipid-transporting ATPase IG isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV31, A0A8I5ZVG5
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:862 → 1090
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    5. XM_039100443.2 → XP_038956371.1  phospholipid-transporting ATPase IG isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV31, A0A8I5ZVG5
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:862 → 1090
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    6. XM_063280570.1 → XP_063136640.1  phospholipid-transporting ATPase IG isoform X5

      UniProtKB/TrEMBL
      A0A8I6AFP3

    7. XM_017602409.3 → XP_017457898.1  phospholipid-transporting ATPase IG isoform X3

      UniProtKB/TrEMBL
      D3ZFC5
      Conserved Domains (2) summary
      cd02073
      Location:43 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:863 → 1091
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    8. XM_017602410.3 → XP_017457899.1  phospholipid-transporting ATPase IG isoform X6

      UniProtKB/TrEMBL
      D3ZFC5
      Conserved Domains (2) summary
      cd02073
      Location:43 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:863 → 1091
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    9. XM_006257597.5 → XP_006257659.1  phospholipid-transporting ATPase IG isoform X4

      See identical proteins and their annotated locations for XP_006257659.1

      UniProtKB/TrEMBL
      D3ZFC5
      Conserved Domains (6) summary
      TIGR01652
      Location:41 → 1089
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:98 → 183
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:469 → 573
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38 → 91
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:863 → 1090
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:812 → 841
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    10. XM_006257599.5 → XP_006257661.1  phospholipid-transporting ATPase IG isoform X1

      See identical proteins and their annotated locations for XP_006257661.1

      UniProtKB/TrEMBL
      A0A8I5ZVG5, A0A8I6AUH5
      Related
      ENSRNOP00000097091.1
      Conserved Domains (6) summary
      TIGR01652
      Location:41 → 1089
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:98 → 183
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:469 → 573
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38 → 91
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:863 → 1090
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:812 → 841
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    11. XM_039100448.2 → XP_038956376.1  phospholipid-transporting ATPase IG isoform X3

      UniProtKB/TrEMBL
      D3ZFC5
      Conserved Domains (2) summary
      cd02073
      Location:43 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:863 → 1091
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    12. XM_039100449.2 → XP_038956377.1  phospholipid-transporting ATPase IG isoform X6

      UniProtKB/TrEMBL
      D3ZFC5
      Conserved Domains (2) summary
      cd02073
      Location:43 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:863 → 1091
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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