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    Csnk1g3 casein kinase 1, gamma 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64823, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Csnk1g3provided by RGD
    Official Full Name
    casein kinase 1, gamma 3provided by RGD
    Primary source
    RGD:621408
    See related
    Ensembl:ENSRNOG00000016677 AllianceGenome:RGD:621408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human CSNK1G3 (casein kinase 1 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 176.2), Thymus (RPKM 175.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (49497839..49584828)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (47299547..47386538)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (48831209..48913341)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 120 Neighboring gene uncharacterized LOC134483022 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 2 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 12 Neighboring gene uncharacterized LOC134483023

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. Zhai L, et al. J Biol Chem, 1995 May 26. PMID 7759525
    2. Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation. Negro A, et al. FASEB J, 2002 Feb. PMID 11744621
    3. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Chia R, et al. Nat Commun, 2014 Dec 15. PMID 25500533, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-3; casein kinase I
    Names
    CKI-gamma 3
    NP_001380678.1
    NP_001380679.1
    NP_074046.1
    XP_063133617.1
    XP_063133618.1
    XP_063133619.1
    XP_063133620.1
    XP_063133621.1
    XP_063133622.1
    XP_063133623.1
    XP_063133625.1
    XP_063133626.1
    XP_063133627.1
    XP_063133628.1
    XP_063133629.1
    XP_063133630.1
    XP_063133631.1
    XP_063133632.1
    XP_063133633.1
    XP_063133634.1
    XP_063133635.1
    XP_063133636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393749.1 → NP_001380678.1  casein kinase I isoform gamma-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0A0MXY3, A0A8I6AUP7, A6IX41
      Related
      ENSRNOP00000097230.1, ENSRNOT00000111040.1
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. NM_001393750.1 → NP_001380679.1  casein kinase I isoform gamma-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0A0MXY3, A6IX40
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. NM_022855.3 → NP_074046.1  casein kinase I isoform gamma-3 isoform 1

      See identical proteins and their annotated locations for NP_074046.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q62763
      UniProtKB/TrEMBL
      A0A0A0MXY3, A6IX39
      Related
      ENSRNOP00000093418.1, ENSRNOT00000103210.1
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      49497839..49584828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277556.1 → XP_063133626.1  casein kinase I isoform X5

    2. XM_063277547.1 → XP_063133617.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3W6, A6IX38

    3. XM_063277557.1 → XP_063133627.1  casein kinase I isoform X6

    4. XM_063277553.1 → XP_063133623.1  casein kinase I isoform X3

    5. XM_063277559.1 → XP_063133629.1  casein kinase I isoform X8

    6. XM_063277563.1 → XP_063133633.1  casein kinase I isoform X11

    7. XM_063277552.1 → XP_063133622.1  casein kinase I isoform X2

    8. XM_063277558.1 → XP_063133628.1  casein kinase I isoform X7

    9. XM_063277555.1 → XP_063133625.1  casein kinase I isoform X4

    10. XM_063277562.1 → XP_063133632.1  casein kinase I isoform X10

    11. XM_063277566.1 → XP_063133636.1  casein kinase I isoform X13

    12. XM_063277549.1 → XP_063133619.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3W6, A6IX38

    13. XM_063277560.1 → XP_063133630.1  casein kinase I isoform X9

      UniProtKB/TrEMBL
      A6IX40

    14. XM_063277564.1 → XP_063133634.1  casein kinase I isoform X12

      UniProtKB/TrEMBL
      A0A8I6AUP7, A6IX41

    15. XM_063277565.1 → XP_063133635.1  casein kinase I isoform X12

      UniProtKB/TrEMBL
      A0A8I6AUP7, A6IX41

    16. XM_063277548.1 → XP_063133618.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3W6, A6IX38

    17. XM_063277561.1 → XP_063133631.1  casein kinase I isoform X9

      UniProtKB/TrEMBL
      A6IX40

    18. XM_063277550.1 → XP_063133620.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3W6, A6IX38

    19. XM_063277551.1 → XP_063133621.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I6G3W6, A6IX38
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62763.1 GenPept UniProtKB/Swiss-Prot:Q62763

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