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    Crlf1 cytokine receptor-like factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290655, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Crlf1provided by RGD
    Official Full Name
    cytokine receptor-like factor 1provided by RGD
    Primary source
    RGD:1311371
    See related
    Ensembl:ENSRNOG00000020030 AllianceGenome:RGD:1311371
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor binding activity and cytokine activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; negative regulation of motor neuron apoptotic process; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within ureteric bud development. Predicted to be part of CRLF-CLCF1 complex and receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 1. Orthologous to human CRLF1 (cytokine receptor like factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 95.5), Brain (RPKM 40.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crlf1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18958695..18970026, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18924722..18936049, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20675042..20686365, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene required for excision 1-B domain containing Neighboring gene transmembrane protein 59-like Neighboring gene kelch-like family member 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. Knappskog PM, et al. Am J Hum Genet, 2003 Feb. PMID 12509788, Free PMC Article
    2. Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. Forger NG, et al. J Neurosci, 2003 Oct 1. PMID 14523086, Free PMC Article
    3. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Elson GC, et al. Nat Neurosci, 2000 Sep. PMID 10966616
    4. Characterizing the new transcription regulator protein p60TRP. Heese K, et al. J Cell Biochem, 2004 Apr 1. PMID 15034937
    5. Spatial gene expression in the T-stage mouse metanephros. Caruana G, et al. Gene Expr Patterns, 2006 Oct. PMID 16545622

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ciliary neurotrophic factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of motor neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CRLF-CLCF1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CRLF-CLCF1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytokine receptor-like factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106074.1 → NP_001099544.1  cytokine receptor-like factor 1 precursor

      See identical proteins and their annotated locations for NP_001099544.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474031
      UniProtKB/TrEMBL
      A6KA48
      Conserved Domains (2) summary
      cd00063
      Location:239 → 341
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:136 → 231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18958695..18970026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094330.2 → XP_038950258.1  cytokine receptor-like factor 1 isoform X1

      Conserved Domains (2) summary
      cd00063
      Location:239 → 341
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:136 → 231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_039094331.2 → XP_038950259.1  cytokine receptor-like factor 1 isoform X2

      Conserved Domains (2) summary
      cd00063
      Location:239 → 341
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:136 → 231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_006252874.5 → XP_006252936.1  cytokine receptor-like factor 1 isoform X4

      Conserved Domains (2) summary
      cd00063
      Location:239 → 341
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:136 → 231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_006252872.5 → XP_006252934.1  cytokine receptor-like factor 1 isoform X3

      UniProtKB/TrEMBL
      D3ZIV9
      Related
      ENSRNOP00000056846.3
      Conserved Domains (2) summary
      cd00063
      Location:239 → 341
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:136 → 231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. XM_039094332.2 → XP_038950260.1  cytokine receptor-like factor 1 isoform X5

      Conserved Domains (2) summary
      cd00063
      Location:239 → 341
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:136 → 231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version

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