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    Armcx3 armadillo repeat containing, X-linked 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367902, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Armcx3provided by RGD
    Official Full Name
    armadillo repeat containing, X-linked 3provided by RGD
    Primary source
    RGD:1549739
    See related
    Ensembl:ENSRNOG00000025730 AllianceGenome:RGD:1549739
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cellular protein localization. Predicted to act upstream of or within axonal transport of mitochondrion; mitochondrion organization; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleus. Predicted to be integral component of mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human ARMCX3 (armadillo repeat containing X-linked 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 383.1), Heart (RPKM 305.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Armcx3 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102230464..102234017)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97937115..97942098)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105573909..105577480)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene protein ARMCX6-like Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene armadillo repeat containing, X-linked 2 Neighboring gene cofilin 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. Mou Z, et al. J Biol Chem, 2009 May 15. PMID 19304657, Free PMC Article
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sox10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3
      Title: The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within axonal transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing X-linked protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014273.1 → NP_001014295.1  armadillo repeat-containing X-linked protein 3

      See identical proteins and their annotated locations for NP_001014295.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083747
      UniProtKB/Swiss-Prot
      Q5XID7
      UniProtKB/TrEMBL
      A0A8I6AF34
      Related
      ENSRNOP00000033859.4, ENSRNOT00000029664.6
      Conserved Domains (2) summary
      sd00043
      Location:156 → 190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112 → 363
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      102230464..102234017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XID7.1 GenPept UniProtKB/Swiss-Prot:Q5XID7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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