Tpst1 tyrosylprotein sulfotransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpst1provided by RGD
Official Full Name: tyrosylprotein sulfotransferase 1provided by RGD
Primary source: RGD:1308473
See related: Ensembl:ENSRNOG00000000900 AllianceGenome:RGD:1308473
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein homodimerization activity and protein-tyrosine sulfotransferase activity. Predicted to be involved in peptidyl-tyrosine sulfation. Predicted to be integral component of Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 120.7), Testes (RPKM 106.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32180688..32247478, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26544536..26605706, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30045753..30112377, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048323 (e-PCR)
- UniSTS:109649

RH136945 (e-PCR)
- UniSTS:219034

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-tyrosine sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-tyrosine sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-tyrosine sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-tyrosine sulfotransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in peptidyl-tyrosine sulfation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein-tyrosine sulfotransferase 1

Names: TPST-1

NP_001011903.2

EC 2.8.2.20

XP_006249296.1

EC 2.8.2.20

XP_063127234.1

EC 2.8.2.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011903.2 → NP_001011903.2 protein-tyrosine sulfotransferase 1

See identical proteins and their annotated locations for NP_001011903.2

Status: PROVISIONAL

Source sequence(s)

BC105826

UniProtKB/Swiss-Prot

Q3KR92

UniProtKB/TrEMBL

A6J0M9, Q6AYS9

Related

ENSRNOP00000001200.4, ENSRNOT00000001200.6

Conserved Domains (1) summary

pfam13469
Location:72 → 261

Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

32180688..32247478 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271164.1 → XP_063127234.1 protein-tyrosine sulfotransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q3KR92

UniProtKB/TrEMBL

A6J0M9
XM_006249234.4 → XP_006249296.1 protein-tyrosine sulfotransferase 1 isoform X2

UniProtKB/TrEMBL

A0A8L2QSG0, Q6AYS9

Related

ENSRNOP00000060104.2

Conserved Domains (1) summary

pfam13469
Location:72 → 261

Sulfotransfer_3; Sulfotransferase family