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    Pias2 protein inhibitor of activated STAT, 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83422, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Pias2provided by RGD
    Official Full Name
    protein inhibitor of activated STAT, 2provided by RGD
    Primary source
    RGD:71056
    See related
    Ensembl:ENSRNOG00000017493 AllianceGenome:RGD:71056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DIP; Miz1; ARIP3; PiasX
    Summary
    Enables nuclear receptor binding activity and protein domain specific binding activity. Involved in several processes, including androgen receptor signaling pathway; positive regulation of dendrite morphogenesis; and response to testosterone. Acts upstream of or within regulation of androgen receptor signaling pathway. Located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 242.6), Adrenal (RPKM 191.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pias2 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (72883008..72989486)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70608034..70714295)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73479863..73524956)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098312 Neighboring gene uncharacterized LOC134483057 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene haloacid dehalogenase-like hydrolase domain containing 2 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene uncharacterized LOC102552068 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene uncharacterized LOC102551787 Neighboring gene lipoxygenase homology PLAT domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study. Chen P, et al. Dig Dis Sci, 2016 Mar. PMID 26581215
    2. ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Buyandelger B, et al. Circ Cardiovasc Genet, 2015 Oct. PMID 26175529
    3. Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signaling. Kotaja N, et al. J Biol Chem, 2002 May 17. PMID 11893729
    4. Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα. Gupta S, et al. Int J Mol Sci, 2021 Dec 7. PMID 34947973, Free PMC Article
    5. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. Shalizi A, et al. J Neurosci, 2007 Sep 12. PMID 17855618, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxalpha.
      Title: Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα.
    2. functions for ZBTB17 in the heart, a transcription factor that may play a role as a novel cardiomyopathy gene
      Title: ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.
    3. Decreasing MIZ1 expression was closely correlated with inflammatory response, and development of acute necrotizing pancreatitis.
      Title: Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study.
    4. Miz-1 is essential for Myc-mediated apoptosis
      Title: Targeting of Miz-1 is essential for Myc-mediated apoptosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear glucocorticoid receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of macromolecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase PIAS2
    Names
    DAB2-interacting protein
    E3 SUMO-protein transferase PIAS2
    androgen receptor-interacting protein 3
    msx-interacting-zinc finger protein
    protein inhibitor of activated STAT x
    NP_001380693.1
    NP_445789.2
    XP_038953070.2
    XP_038953071.2
    XP_038953072.1
    XP_038953073.2
    XP_038953074.2
    XP_038953075.1
    XP_038953077.1
    XP_038953079.2
    XP_038953080.2
    XP_038953081.2
    XP_038953082.2
    XP_038953083.2
    XP_063133673.1
    XP_063133674.1
    XP_063133675.1
    XP_063133676.1
    XP_063133677.1
    XP_063133678.1
    XP_063133679.1
    XP_063133680.1
    XP_063133681.1
    XP_063133682.1
    XP_063133683.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393764.1 → NP_001380693.1  E3 SUMO-protein ligase PIAS2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KMU4
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147 → 296
      PINIT; PINIT domain

    2. NM_053337.2 → NP_445789.2  E3 SUMO-protein ligase PIAS2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q6AZ28, Q9Z177
      UniProtKB/TrEMBL
      A6KMU1
      Related
      ENSRNOP00000023886.5, ENSRNOT00000023886.6
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147 → 296
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      72883008..72989486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097146.2 → XP_038953074.2  E3 SUMO-protein ligase PIAS2 isoform X7

      UniProtKB/TrEMBL
      A6KMU6

    2. XM_039097154.2 → XP_038953082.2  E3 SUMO-protein ligase PIAS2 isoform X11

      UniProtKB/TrEMBL
      F1LRP3

    3. XM_063277603.1 → XP_063133673.1  E3 SUMO-protein ligase PIAS2 isoform X1

      UniProtKB/TrEMBL
      A6KMU4

    4. XM_039097142.2 → XP_038953070.2  E3 SUMO-protein ligase PIAS2 isoform X2

      UniProtKB/TrEMBL
      A6KMU4

    5. XM_039097143.2 → XP_038953071.2  E3 SUMO-protein ligase PIAS2 isoform X3

      UniProtKB/TrEMBL
      A6KMU6

    6. XM_039097152.2 → XP_038953080.2  E3 SUMO-protein ligase PIAS2 isoform X11

      UniProtKB/TrEMBL
      F1LRP3

    7. XM_039097151.2 → XP_038953079.2  E3 SUMO-protein ligase PIAS2 isoform X11

      UniProtKB/TrEMBL
      F1LRP3

    8. XM_039097153.2 → XP_038953081.2  E3 SUMO-protein ligase PIAS2 isoform X11

      UniProtKB/TrEMBL
      F1LRP3

    9. XM_039097145.2 → XP_038953073.2  E3 SUMO-protein ligase PIAS2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AHS4

    10. XM_039097155.2 → XP_038953083.2  E3 SUMO-protein ligase PIAS2 isoform X12

      UniProtKB/TrEMBL
      F1LRP3

    11. XM_063277604.1 → XP_063133674.1  E3 SUMO-protein ligase PIAS2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A470, A6KMU4

    12. XM_063277606.1 → XP_063133676.1  E3 SUMO-protein ligase PIAS2 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AHS4

    13. XM_039097144.2 → XP_038953072.1  E3 SUMO-protein ligase PIAS2 isoform X4

      UniProtKB/TrEMBL
      A6KMU4
      Related
      ENSRNOP00000086650.1
      Conserved Domains (3) summary
      smart00513
      Location:41 → 75
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:373 → 420
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:177 → 326
      PINIT; PINIT domain

    14. XM_063277609.1 → XP_063133679.1  E3 SUMO-protein ligase PIAS2 isoform X16

      UniProtKB/TrEMBL
      A0A8I6B6K3, A0A8I6GLW8

    15. XM_039097147.2 → XP_038953075.1  E3 SUMO-protein ligase PIAS2 isoform X8

      UniProtKB/TrEMBL
      A6KMU4
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147 → 296
      PINIT; PINIT domain

    16. XM_063277607.1 → XP_063133677.1  E3 SUMO-protein ligase PIAS2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6B6K3

    17. XM_063277611.1 → XP_063133681.1  E3 SUMO-protein ligase PIAS2 isoform X18

      UniProtKB/TrEMBL
      F1LRP3

    18. XM_063277612.1 → XP_063133682.1  E3 SUMO-protein ligase PIAS2 isoform X19

      UniProtKB/TrEMBL
      F1LRP3

    19. XM_063277605.1 → XP_063133675.1  E3 SUMO-protein ligase PIAS2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GK87, A6KMU4

    20. XM_063277608.1 → XP_063133678.1  E3 SUMO-protein ligase PIAS2 isoform X15

      UniProtKB/TrEMBL
      A6KMU6

    21. XM_039097149.2 → XP_038953077.1  E3 SUMO-protein ligase PIAS2 isoform X9

      UniProtKB/TrEMBL
      A6KMU2, A6KMU4
      Related
      ENSRNOP00000092581.1
      Conserved Domains (3) summary
      smart00513
      Location:4 → 38
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:140 → 289
      PINIT; PINIT domain

    22. XM_063277610.1 → XP_063133680.1  E3 SUMO-protein ligase PIAS2 isoform X17

      UniProtKB/TrEMBL
      A0A8I6AHS4, A6KMU3

    23. XM_063277613.1 → XP_063133683.1  E3 SUMO-protein ligase PIAS2 isoform X20

      UniProtKB/TrEMBL
      F1LRP3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AZ28.1 GenPept UniProtKB/Swiss-Prot:Q6AZ28

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