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    ZNF879 zinc finger protein 879 [ Homo sapiens (human) ]

    Gene ID: 345462, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF879provided by HGNC
    Official Full Name
    zinc finger protein 879provided by HGNC
    Primary source
    HGNC:HGNC:37273
    See related
    Ensembl:ENSG00000234284 AllianceGenome:HGNC:37273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKFZp686E2433
    Summary
    This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]
    Expression
    Broad expression in testis (RPKM 2.9), thyroid (RPKM 1.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF879 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (179023804..179035064)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (179576953..179588262)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178450805..178462065)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 454 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83773 Neighboring gene F-box and WD repeat domain containing 2 pseudogene Neighboring gene glutamate metabotropic receptor 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:178450433-178450934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:178487693-178488228 Neighboring gene zinc finger protein 354C Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178594089-178594590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178608229-178608956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178611336-178611936 Neighboring gene uncharacterized LOC124900195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178619033-178619724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kruppel-associated box (KRAB) proteins in the adaptive immune system. Santoni de Sio FR. Nucleus, 2014 Mar-Apr. PMID 24699165, Free PMC Article
    2. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Imbeault M, et al. Nature, 2017 Mar 23. PMID 28273063
    3. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. Wang W, et al. PLoS One, 2014. PMID 24647005, Free PMC Article
    4. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. Wang J, et al. Yi Chuan, 2016 Nov 20. PMID 27867147
    5. Cys2His2 zinc finger protein family: classification, functions, and major members. Razin SV, et al. Biochemistry (Mosc), 2012 Mar. PMID 22803940

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 879

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136116.3 → NP_001129588.1  zinc finger protein 879

      See identical proteins and their annotated locations for NP_001129588.1

      Status: REVIEWED

      Source sequence(s)
      AC104117, AK300504, BM971752, BX114675, BX648737, DC350553
      Consensus CDS
      CCDS47352.1
      UniProtKB/Swiss-Prot
      B4DU55
      Related
      ENSP00000414887.2, ENST00000444149.7
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:202 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001353372.2 → NP_001340301.1  zinc finger protein 879

      Status: REVIEWED

      Source sequence(s)
      AC104117, BM971752
      Consensus CDS
      CCDS47352.1
      UniProtKB/Swiss-Prot
      B4DU55
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:202 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001353373.2 → NP_001340302.1  zinc finger protein 879

      Status: REVIEWED

      Source sequence(s)
      AC104117, BM971752
      Consensus CDS
      CCDS47352.1
      UniProtKB/Swiss-Prot
      B4DU55
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:202 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001353374.2 → NP_001340303.1  zinc finger protein 879

      Status: REVIEWED

      Source sequence(s)
      AC104117, BM971752
      Consensus CDS
      CCDS47352.1
      UniProtKB/Swiss-Prot
      B4DU55
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:202 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      179023804..179035064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534551.3 → XP_011532853.1  zinc finger protein 879 isoform X1

      See identical proteins and their annotated locations for XP_011532853.1

      UniProtKB/Swiss-Prot
      B4DU55
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:202 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_047417144.1 → XP_047273100.1  zinc finger protein 879 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      179576953..179588262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352508.1 → XP_054208483.1  zinc finger protein 879 isoform X1

      UniProtKB/Swiss-Prot
      B4DU55

    2. XM_054352509.1 → XP_054208484.1  zinc finger protein 879 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4DU55.2 GenPept UniProtKB/Swiss-Prot:B4DU55

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