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    NECTIN2 nectin cell adhesion molecule 2 [ Bos taurus (cattle) ]

    Gene ID: 505580, updated on 6-Jun-2024

    Summary

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    Official Symbol
    NECTIN2provided by VGNC
    Official Full Name
    nectin cell adhesion molecule 2provided by VGNC
    Primary source
    VGNC:VGNC:52209
    See related
    BGD:BT18926; Ensembl:ENSBTAG00000015318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    prr2; PVRL2
    Orthologs
    human mouse all
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    Genomic context

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    See NECTIN2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (52582150..52615253)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342865 Neighboring gene Cbl proto-oncogene C Neighboring gene basal cell adhesion molecule Neighboring gene large ribosomal subunit protein eL15-like Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene apolipoprotein E

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Host range of poliovirus is restricted to simians because of a rapid sequence change of the poliovirus receptor gene during evolution. Ida-Hosonuma M, et al. Arch Virol, 2003 Jan. PMID 12536294
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140511

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in coreceptor-mediated virion attachment to host cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of mitochondrion localization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fusion of virus membrane with host plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mast cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in susceptibility to T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in susceptibility to natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical junction complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nectin-2
    Names
    poliovirus receptor-related 2 (herpesvirus entry mediator B)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075210.2 → NP_001068678.1  nectin-2 precursor

      See identical proteins and their annotated locations for NP_001068678.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118434
      UniProtKB/TrEMBL
      A0A3Q1LZJ0, F1MTV8, Q17QC7
      Conserved Domains (4) summary
      cd05718
      Location:49 → 162
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      smart00410
      Location:43 → 161
      IG_like; Immunoglobulin like
      pfam13927
      Location:263 → 336
      Ig_3; Immunoglobulin domain
      cl11960
      Location:165 → 260
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      52582150..52615253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005219196.3 → XP_005219253.1  nectin-2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MRJ9
      Related
      ENSBTAP00000056981.1, ENSBTAT00000070790.2
      Conserved Domains (4) summary
      cd05718
      Location:49 → 162
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      smart00410
      Location:43 → 161
      IG_like; Immunoglobulin like
      pfam13927
      Location:263 → 336
      Ig_3; Immunoglobulin domain
      cl11960
      Location:165 → 260
      Ig; Immunoglobulin domain

    2. XM_005219198.3 → XP_005219255.1  nectin-2 isoform X2

      UniProtKB/TrEMBL
      A0AAF6DLP8
      Related
      ENSBTAP00000020364.7, ENSBTAT00000020364.7
      Conserved Domains (4) summary
      cd05718
      Location:49 → 162
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      smart00410
      Location:43 → 161
      IG_like; Immunoglobulin like
      pfam13927
      Location:263 → 336
      Ig_3; Immunoglobulin domain
      cl11960
      Location:165 → 260
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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