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    IBSP integrin binding sialoprotein [ Bos taurus (cattle) ]

    Gene ID: 281233, updated on 14-Apr-2024

    Summary

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    Official Symbol
    IBSPprovided by VGNC
    Official Full Name
    integrin binding sialoproteinprovided by VGNC
    Primary source
    VGNC:VGNC:30021
    See related
    BGD:BT10826; Ensembl:ENSBTAG00000000470
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See IBSP in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (36879556..36893874, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447053 Neighboring gene uncharacterized LOC132345488 Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene uncharacterized LOC112447150 Neighboring gene uncharacterized LOC132345489 Neighboring gene transfer RNA alanine (anticodon CGC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study reveals that the IBSP locus affects ear size in cattle. Shen J, et al. Heredity (Edinb), 2023 Jun. PMID 37016135,
    2. Cloning and sequence analysis of bovine bone sialoprotein cDNA: conservation of acidic domains, tyrosine sulfation consensus repeats, and RGD cell attachment domain. Chenu C, et al. J Bone Miner Res, 1994 Mar. PMID 7514841
    3. Complete topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein and their biological implications. Salih E, et al. J Biol Chem, 2004 May 7. PMID 15004024
    4. A potential role for tetranectin in mineralization during osteogenesis. Wewer UM, et al. J Cell Biol, 1994 Dec. PMID 7798325, Free PMC Article
    5. Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases. Salih E, et al. J Biol Chem, 1996 Jul 12. PMID 8663267

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide association study reveals that the IBSP locus affects ear size in cattle.
      Title: Genome-wide association study reveals that the IBSP locus affects ear size in cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in bone mineralization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin-binding sialoprotein; bone sialoprotein 2
    Names
    BSP II
    bone sialoprotein II
    cell-binding sialoprotein
    integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174084.3 → NP_776509.1  integrin-binding sialoprotein precursor

      See identical proteins and their annotated locations for NP_776509.1

      Status: PROVISIONAL

      Source sequence(s)
      S73144
      UniProtKB/Swiss-Prot
      Q28862
      Related
      ENSBTAP00000000595.2, ENSBTAT00000000595.3
      Conserved Domains (1) summary
      pfam05432
      Location:17 → 307
      BSP_II; Bone sialoprotein II (BSP-II)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      36879556..36893874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059887312.1 → XP_059743295.1  bone sialoprotein 2 isoform X2

      Related
      ENSBTAP00000083315.1, ENSBTAT00000091455.1

    2. XM_010806004.3 → XP_010804306.1  bone sialoprotein 2 isoform X1

      See identical proteins and their annotated locations for XP_010804306.1

      UniProtKB/Swiss-Prot
      Q28862
      Conserved Domains (1) summary
      pfam05432
      Location:17 → 307
      BSP_II; Bone sialoprotein II (BSP-II)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28862.1 GenPept UniProtKB/Swiss-Prot:Q28862

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.