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    TTN titin [ Gallus gallus (chicken) ]

    Gene ID: 424126, updated on 6-Jun-2024

    Summary

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    Symbol
    TTNprovided by CGNC
    Full Name
    titinprovided by CGNC
    Primary source
    CGNC:52134
    See related
    Ensembl:ENSGALG00010022969
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TTN in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    328
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (14758023..15007017)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (14684769..14924606)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene SEC14 and spectrin domain containing 1 Neighboring gene coiled-coil domain containing 141 Neighboring gene myosin light chain kinase, smooth muscle-like Neighboring gene titin-like Neighboring gene microRNA 7474 Neighboring gene pleckstrin homology domain containing A3 Neighboring gene deafness, autosomal recessive 59 Neighboring gene FK506 binding protein 7 Neighboring gene oxysterol binding protein like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Smooth muscle titin forms in vitro amyloid aggregates. Bobylev AG, et al. Biosci Rep, 2016 Jul. PMID 27129292, Free PMC Article
    2. Chicken breast muscle connectin: passive tension and I-band region primary structure. Noguchi H, et al. J Mol Biol, 2007 Jul 6. PMID 17512946
    3. Targeting of cardiac muscle titin fragments to the Z-bands and dense bodies of living muscle and non-muscle cells. Ayoob JC, et al. Cell Motil Cytoskeleton, 2000 Jan. PMID 10618168
    4. The N-terminal Z repeat 5 of connectin/titin binds to the C-terminal region of alpha-actinin. Ohtsuka H, et al. Biochem Biophys Res Commun, 1997 Jun 9. PMID 9196024
    5. Partial characterization of zeugmatin indicates that it is part of the Z-band region of titin. Turnacioglu KK, et al. Cell Motil Cytoskeleton, 1996. PMID 8769723

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nonspecific Amyloid Aggregation of Chicken Smooth-Muscle Titin: In Vitro Investigations.
      Title: Nonspecific Amyloid Aggregation of Chicken Smooth-Muscle Titin: In Vitro Investigations.
    2. The present study, reports that smooth muscle titin (SMT; 500 kDa) from chicken gizzard forms amyloid aggregates in vitro .
      Title: Smooth muscle titin forms in vitro amyloid aggregates.
    3. titin splice diversity regulates structure and biomechanics of the sarcomere
      Title: Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.
    4. There were fewer middle immunoglobulin domains and amino acid residues in the PEVK segment of chicken breast muscle connectin than in human skeletal muscle connectin, but more than in human cardiac muscle connectin.
      Title: Chicken breast muscle connectin: passive tension and I-band region primary structure.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    titin
    Names
    connectin
    XP_046777675.1
    XP_046799681.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      14758023..15007017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943725.1 → XP_046799681.1  titin isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZUU8
      Related
      ENSGALP00010033919.1, ENSGALT00010056066.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      14684769..14924606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921719.1 → XP_046777675.1  titin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZUU8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001319997.1: Suppressed sequence

      Description
      NM_001319997.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: TTN (GeneID:540561).
    Nucleotide Protein Strain
    Heading Accession and Version

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