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    PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 [ Gallus gallus (chicken) ]

    Gene ID: 395729, updated on 5-Mar-2024

    Summary

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    Symbol
    PCBD1provided by CGNC
    Full Name
    pterin-4 alpha-carbinolamine dehydratase 1provided by CGNC
    Primary source
    CGNC:20211
    See related
    Ensembl:ENSGALG00010020346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PCD; PHS; DCOH
    Orthologs
    human mouse all
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    Genomic context

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    See PCBD1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (12329037..12333018, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (12375004..12378995, complement)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene microsomal triglyceride transfer protein-like Neighboring gene sphingosine-1-phosphate lyase 1 Neighboring gene uncharacterized LOC124418060 Neighboring gene unc-5 netrin receptor B Neighboring gene solute carrier family 29 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of chicken dimerization cofactor of hepatocyte nuclear factor-1 (DcoH) and its novel counterpart, DcoHalpha. Kim H, et al. Biochem J, 2001 Mar 15. PMID 11237869, Free PMC Article
    2. Characterization of the chicken and rat DCoH gene domains using an improved ligation-mediated PCR method. Bossow S, et al. Biol Chem, 1998 Nov. PMID 9865610
    3. Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Carre W, et al. Physiol Genomics, 2006 May 16. PMID 16554550
    4. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pterin-4-alpha-carbinolamine dehydratase
    Names
    4-alpha-hydroxy-tetrahydropterin dehydratase
    6-pyruvoyl-tetrahydropterin synthase
    cDcoH
    dimerization cofactor of HNF1
    dimerization cofactor of hepatocyte nuclear factor 1-alpha
    phenylalanine hydroxylase-stimulating protein
    pterin carbinolamine dehydratase
    pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
    NP_990236.1
    XP_046775862.1
    XP_046798685.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204905.2 → NP_990236.1  pterin-4-alpha-carbinolamine dehydratase

      See identical proteins and their annotated locations for NP_990236.1

      Status: VALIDATED

      Source sequence(s)
      BM490804, BU422064
      UniProtKB/Swiss-Prot
      O73930
      UniProtKB/TrEMBL
      A0A8V0ZDX6
      Related
      ENSGALP00010029058.1, ENSGALT00010049148.1
      Conserved Domains (1) summary
      cd00914
      Location:24 → 99
      PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12329037..12333018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046942729.1 → XP_046798685.1  pterin-4-alpha-carbinolamine dehydratase isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12375004..12378995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046919906.1 → XP_046775862.1  pterin-4-alpha-carbinolamine dehydratase isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73930.3 GenPept UniProtKB/Swiss-Prot:O73930

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